Guarda Vittoria, Pickhard Anja, Boxberg Melanie, Specht Katja, Buchberger Anna Maria Stefanie
Department of Otolaryngology, Head and Neck Surgery, Technical University of Munich, Munich, Germany.
Institute of Pathology, Technical University of Munich, Munich, Germany.
Eur Thyroid J. 2018 Mar;7(2):102-108. doi: 10.1159/000486333. Epub 2018 Jan 19.
Liposarcomas of the thyroid gland are extremely rare tumors, and, to our knowledge, only 12 cases have been reported in the English literature. An accurate diagnosis is challenging due to the nonspecific clinical presentation of this cancer, frequently defined just by a swelling of the neck.
We present an 82-year-old woman with liposarcoma of the thyroid, complaining of a fast-growing neck mass. MRI and neck ultrasound showed a large lipomatous mass, which corresponded to a nodule in the thyroid scan. After performing a total thyroidectomy, the diagnosis of a well-differentiated liposarcoma of the thyroid gland was made, showing an MDM2 amplification in fluorescence in situ hybridization. Since neither a metastasis nor a residual tumor was found, no further adjuvant therapy was needed.
We searched the literature for previous case reports and identified only 12 cases worldwide to form our database. A demographic as well as clinical and histopathological analysis was made. In most cases, the liposarcoma occurred in patients >60 years of age. All histological subtypes, such as well-differentiated and myxoid liposarcomas, and pleomorphic and dedifferentiated liposarcomas, were found in the literature. In only 38.46% of the cases, an infiltration of the adjacent organs was observed. Surgery was the most common treatment chosen.
Our review provides clinical and histopathological features of a primary liposarcoma of the thyroid to enable the identifi-cation of this rare tumor entity and assist in the decision-making process regarding therapeutic options and tumor follow-up.
甲状腺脂肪肉瘤是极其罕见的肿瘤，据我们所知，英文文献中仅报道过12例。由于这种癌症的临床表现不具有特异性，常常仅表现为颈部肿胀，因此准确诊断具有挑战性。
我们报告一名82岁患有甲状腺脂肪肉瘤的女性，主诉颈部肿物生长迅速。MRI和颈部超声显示一个巨大的脂肪瘤样肿物，在甲状腺扫描中对应一个结节。在进行全甲状腺切除术后，诊断为甲状腺高分化脂肪肉瘤，荧光原位杂交显示MDM2扩增。由于未发现转移或残留肿瘤，无需进一步辅助治疗。
我们检索文献以查找既往病例报告，在全球仅确定了12例以形成我们的数据库。进行了人口统计学以及临床和组织病理学分析。在大多数情况下，脂肪肉瘤发生于60岁以上的患者。文献中发现了所有组织学亚型，如高分化和黏液样脂肪肉瘤，以及多形性和去分化脂肪肉瘤。仅在38.46%的病例中观察到邻近器官受侵。手术是最常用的治疗方法。
我们的综述提供了甲状腺原发性脂肪肉瘤的临床和组织病理学特征，以便能够识别这种罕见的肿瘤实体，并协助进行有关治疗选择和肿瘤随访的决策过程。
