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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Fitzgibbon W, Morgan T

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):169-74. doi: 10.1111/j.1440-1681.1987.tb00370.x.

The effect of a low dose of a synthetic atrial natriuretic peptide (ANP), rat atriopeptin II (23 amino acids), on stop-flow sodium concentrations was examined in rabbits in water diuresis. 2. Atrial natriuretic peptide (2 micrograms/kg body weight) was injected intravenously as a bolus either before or after the commencement of stop-flow. 3. Atrial natriuretic peptide induced a significant natriuresis within 2 min of injection. This natriuresis was associated with smaller increases in urine volume and potassium excretion. Atrial natriuretic peptide did not alter blood pressure. 4. Atrial natriuretic peptide did not significantly alter stop-flow sodium concentrations. 5. These findings indicate that ANP does not directly alter sodium transport across medullary collecting ducts. 6. It is proposed that ANP acts via a mediator to alter sodium movement across terminal segments of the nephron.

在水利尿状态下，研究了低剂量合成心房利钠肽（ANP）——大鼠心房肽II（23个氨基酸）对兔停流钠浓度的影响。2. 在停流开始前或开始后，以静脉推注的方式注射心房利钠肽（2微克/千克体重）。3. 心房利钠肽在注射后2分钟内引起显著的利钠作用。这种利钠作用与尿量和钾排泄量的较小增加有关。心房利钠肽未改变血压。4. 心房利钠肽未显著改变停流钠浓度。5. 这些发现表明，ANP不会直接改变髓质集合管的钠转运。6. 有人提出，ANP通过一种介质起作用，以改变钠在肾单位终末段的移动。

Fitzgibbon W, Morgan T

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):169-74. doi: 10.1111/j.1440-1681.1987.tb00370.x.

The effect of a low dose of a synthetic atrial natriuretic peptide (ANP), rat atriopeptin II (23 amino acids), on stop-flow sodium concentrations was examined in rabbits in water diuresis. 2. Atrial natriuretic peptide (2 micrograms/kg body weight) was injected intravenously as a bolus either before or after the commencement of stop-flow. 3. Atrial natriuretic peptide induced a significant natriuresis within 2 min of injection. This natriuresis was associated with smaller increases in urine volume and potassium excretion. Atrial natriuretic peptide did not alter blood pressure. 4. Atrial natriuretic peptide did not significantly alter stop-flow sodium concentrations. 5. These findings indicate that ANP does not directly alter sodium transport across medullary collecting ducts. 6. It is proposed that ANP acts via a mediator to alter sodium movement across terminal segments of the nephron.

在水利尿状态下，研究了低剂量合成心房利钠肽（ANP）——大鼠心房肽II（23个氨基酸）对兔停流钠浓度的影响。2. 在停流开始前或开始后，以静脉推注的方式注射心房利钠肽（2微克/千克体重）。3. 心房利钠肽在注射后2分钟内引起显著的利钠作用。这种利钠作用与尿量和钾排泄量的较小增加有关。心房利钠肽未改变血压。4. 心房利钠肽未显著改变停流钠浓度。5. 这些发现表明，ANP不会直接改变髓质集合管的钠转运。6. 有人提出，ANP通过一种介质起作用，以改变钠在肾单位终末段的移动。