Sonnenberg H, Honrath U, Chong C K, Wilson D R
Am J Physiol. 1986 Jun;250(6 Pt 2):F963-6. doi: 10.1152/ajprenal.1986.250.6.F963.
Characteristics of sodium transport in the inner medullary collecting duct were determined in anesthetized rats before and during intravenous infusion of synthetic atrial natriuretic factor (atriopeptin II). Infusion of the factor was associated with increased sodium delivery and reduced fractional reabsorption in the duct. Increasing delivery to the same extent by KCl infusion had no effect on fractional reabsorption. The results demonstrate that atrial natriuretic factor has a specific inhibitory effect on net sodium transport in this part of the nephron. The mechanism of this inhibition may involve induction of sodium permeability and consequent backflux into the tubular lumen.
在麻醉大鼠静脉输注合成心钠素（心房肽II）之前及期间，测定了其髓质集合管中钠转运的特征。输注该因子与集合管中钠输送增加及分数重吸收减少有关。通过输注氯化钾使输送增加相同程度，对分数重吸收无影响。结果表明，心钠素对肾单位这一部分的钠净转运具有特异性抑制作用。这种抑制机制可能涉及诱导钠通透性并导致钠回流至肾小管管腔。
