Pitzalis C, Kingsley G, Murphy J, Panayi G
Rheumatology Unit, United Medical School, Guy's Hospital, London, United Kingdom.
Clin Immunol Immunopathol. 1987 Nov;45(2):252-8. doi: 10.1016/0090-1229(87)90040-7.
T lymphocytes can be divided into two main phenotypic populations, CD4 and CD8. These can be further subdivided into 2H4, 4B4, or UCHL1 subsets by appropriate monoclonal antibodies. We have investigated these subsets in the synovial fluid of patients with rheumatoid arthritis and have found (i) a virtual absence of CD4+ 2H4+ and the marked reduction of CD8+ 2H4+ T cells; (ii) a marked increase of CD4+ 4B4+ and CD8+ 4B4+ T cells; and (iii) a marked increase of CD4+ UCHL1+ and CD8+ UCHL1+ T cells compared with peripheral blood. Although the functions of the CD8 subsets are not known, the virtual absence of CD4+ 2H4+ suppressor-inducer T cells and the marked increase of CD4+ 4B4+ helper-inducer T cells and of CD4+ UCHL1+ memory T cells may help to explain the many known functional immunological properties of synovial T cells.
T淋巴细胞可分为两个主要的表型群体，即CD4和CD8。通过合适的单克隆抗体，这些群体可进一步细分为2H4、4B4或UCHL1亚群。我们研究了类风湿性关节炎患者滑液中的这些亚群，发现：（i）几乎不存在CD4+ 2H4+，且CD8+ 2H4+ T细胞显著减少；（ii）CD4+ 4B4+和CD8+ 4B4+ T细胞显著增加；（iii）与外周血相比，CD4+ UCHL1+和CD8+ UCHL1+ T细胞显著增加。尽管CD8亚群的功能尚不清楚，但CD4+ 2H4+抑制诱导性T细胞几乎不存在，以及CD4+ 4B4+辅助诱导性T细胞和CD4+ UCHL1+记忆性T细胞显著增加，这可能有助于解释滑膜T细胞许多已知的功能性免疫特性。
