Kingsley G, Pitzalis C, Kyriazis N, Panayi G S
Department of Medicine, Guy's Hospital, London, UK.
Scand J Immunol. 1988 Aug;28(2):225-32. doi: 10.1111/j.1365-3083.1988.tb02435.x.
We have previously shown that rheumatoid synovial T cells are virtually all helper-inducer (CD4+4B4+UCHL1+) rather than suppressor-inducer (CD4+2H4+) cells. CD8 cells were also largely 4B4+. In addition, the majority of T cells were HLA-DR+. To investigate whether these findings were specific for rheumatoid disease, we studied the prevalence of these markers in a variety of chronic inflammatory arthropathies such as ankylosing spondylitis, Reiter's syndrome, and psoriatic arthritis. Again, almost 90% of the T cells were 4B4+UCHL1+ and only 11% were 2H4+; 50% expressed the HLA DR antigen. Thus this phenotypic distribution represents a final common pathway of chronic synovitis and may help to explain the immunopathology of the lesion.
我们先前已经表明，类风湿性滑膜T细胞实际上几乎都是辅助诱导型（CD4+4B4+UCHL1+）而非抑制诱导型（CD4+2H4+）细胞。CD8细胞也大多为4B4+。此外，大多数T细胞为HLA-DR+。为了研究这些发现是否是类风湿性疾病所特有的，我们研究了这些标志物在多种慢性炎症性关节病（如强直性脊柱炎、赖特综合征和银屑病关节炎）中的患病率。同样，几乎90%的T细胞为4B4+UCHL1+，只有11%为2H4+；50%表达HLA DR抗原。因此，这种表型分布代表了慢性滑膜炎的最终共同途径，可能有助于解释病变的免疫病理学。
