Department of Internal Medicine, University of Tübingen, Tübingen, Germany.
Department of Pathobiology and Medical Biotechnologies, University of Palermo, Palermo, Italy.
Aging Clin Exp Res. 2019 Jan;31(1):125-133. doi: 10.1007/s40520-018-0936-7. Epub 2018 Mar 28.
Immunosenescence constitutes a major indirect cause of morbidity and mortality in the elderly. Previous analysis of immune signatures in a cohort of centenarian offspring showed an intermediate immunophenotype between age-matched and younger controls.
To confirm and extend the previous studies performing further phenotypical analysis in centenarian offspring and controls.
Analysis of Treg cells, γδ T cells, mucosal-associated invariant T cells, and senescent immune T cells was performed in centenarian offspring and controls.
We report significant differences between elderly and centenarian offspring in most of the studied subsets, showing that centenarian offspring subsets present an intermediate phenotyping between elderly and younger people.
The whole present data confirm and extend the previous results showing that centenarian offspring retain more youthful immunological parameters and that the exhaustion of the immune system is less evident than in elderly without centenarian parents, though further investigations are warranted.
免疫衰老构成老年人发病率和死亡率的一个主要间接原因。先前对百岁老人后代的免疫特征进行的分析显示，其免疫表型介于年龄匹配的对照组和年轻对照组之间。
通过对百岁老人后代和对照组进行进一步的表型分析，对先前的研究进行确认和扩展。
对百岁老人后代和对照组中的 Treg 细胞、γδ T 细胞、黏膜相关不变 T 细胞和衰老免疫 T 细胞进行分析。
我们报告了在大多数研究亚群中，老年人和百岁老人后代之间存在显著差异，这表明百岁老人后代的表型介于老年人和年轻人之间。
目前的全部数据证实并扩展了先前的研究结果，即百岁老人后代保留了更多年轻的免疫参数，与没有百岁老人父母的老年人相比，免疫系统的衰竭不那么明显，但需要进一步研究。
