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下尿路症状与肠易激综合征之间的关系：横断面研究的荟萃分析。

The relationship between lower urinary tract symptoms and irritable bowel syndrome: a meta-analysis of cross-sectional studies.

作者信息

Li Zhihu, Huang Wei, Wang Xiaoyan, Zhang Yong

机构信息

Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Neurology Research Division, China National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China -

出版信息

Minerva Urol Nefrol. 2018 Aug;70(4):386-392. doi: 10.23736/S0393-2249.18.03044-8. Epub 2018 Mar 28.

DOI:10.23736/S0393-2249.18.03044-8
PMID:29595038
Abstract

INTRODUCTION

While several epidemiologic studies have investigated the relationship between lower urinary tract symptoms (LUTS) and irritable bowel syndrome (IBS), it remains unclear. To investigate the relationship between IBS and LUTS, a systematic review and meta-analysis of cross-sectional studies was carried out.

EVIDENCE ACQUISITION

Online databases were searched up to December 1st, 2017 for cross-sectional studies that evaluated the association between IBS and the risk of LUTS. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.

EVIDENCE SYNTHESIS

In all, 9 articles that contained 19907 participants and 2620 cases of LUTS were included in this meta-analysis. Compared with the non-IBS group, the IBS group had a higher risk of LUTS (total OR=2.11, 95% CI: 1.91-2.33, P<0.00001). Patients with IBS were more likely to have urine storage symptoms (total OR=1.80, 95% CI: 1.34-2.42, P<0.0001). Subgroup analysis by gender showed that the IBS group had a higher risk of LUTS in both men (total OR=2.17, 95% CI: 1.82-2.58, P<0.00001) and women (total OR=1.85, 95% CI: 1.57-2.17, P<0.00001).

CONCLUSIONS

Our meta-analysis provides evidence that IBS is associated with an increased risk of LUTS in both men and women.

摘要

引言

虽然多项流行病学研究调查了下尿路症状（LUTS）与肠易激综合征（IBS）之间的关系，但仍不明确。为了研究IBS与LUTS之间的关系，我们对横断面研究进行了系统评价和荟萃分析。

证据获取

检索在线数据库至2017年12月1日，查找评估IBS与LUTS风险之间关联的横断面研究。计算汇总比值比（OR）和95%置信区间（95%CI）。

证据综合

本荟萃分析共纳入9篇文章，包含19907名参与者和2620例LUTS病例。与非IBS组相比，IBS组发生LUTS的风险更高（总体OR = 2.11，95%CI：1.91 - 2.33，P < 0.00001）。IBS患者更易出现储尿期症状（总体OR = 1.80，95%CI：1.34 - 2.42，P < 0.0001）。按性别进行的亚组分析显示，IBS组男性（总体OR = 2.17，95%CI：1.82 - 2.58，P < 0.00001）和女性（总体OR = 1.85，95%CI：1.57 - 2.17，P < 0.00001）发生LUTS的风险均更高。

结论

我们的荟萃分析提供了证据，表明IBS与男性和女性发生LUTS的风险增加相关。

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