Hwang Jiwon, Ryu Seungho, Ahn Joong Kyong
Division of Rheumatology, Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, 158 Paryong-ro, Masanhoewon-gu, Changwon 51353, Korea.
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Samsung Main Building B2, 67 Sejong-daero, Jung-gu, Seoul 04514, Korea.
Metabolites. 2022 Jul 14;12(7):649. doi: 10.3390/metabo12070649.
Gout has been correlated with the risk of incident benign prostatic hyperplasia. In line with increasing prevalence of hyperuricemia, the aim of this study was to investigate the relationship between serum uric acid (SUA) level and the incidence of lower urinary tract symptoms (LUTS) among clinically healthy middle-aged men. We performed a cohort study in 101,091 Korean men without LUTS at baseline who completed health checkups between 2011 and 2016. LUTS were evaluated using the International Prostate Symptom Score, where a score ≥ 8 was defined as significant LUTS. Men were divided into six groups according to their SUA levels in mg/dL (<5.5, 5.5−6.4, 6.5−7.4, 7.5−8.4, 8.5−9.4, and ≥9.5). Throughout the follow-up—encompassing a total of 358,982.6 person years—13,424 people had significant LUTS (37.3 per 1000 person years for incidence rate). The multivariable models demonstrated that the highest level of SUA (≥9.5 mg/dL) was related to the lowest risk of significant LUTS compared with the reference category (<5.5 mg/dL) (0.77 (95% CI 0.59−0.99) for adjusted HR). In this large cohort composed of middle-aged men, higher SUA levels were related to a reduced risk of LUTS. This result suggests another potential role of SUA in restraining LUTS. Additional studies are needed to explain the underlying biological mechanisms of this phenomenological relationship.
痛风与良性前列腺增生的发病风险相关。随着高尿酸血症患病率的上升，本研究旨在探讨临床健康的中年男性血清尿酸（SUA）水平与下尿路症状（LUTS）发生率之间的关系。我们对101,091名基线时无LUTS且在2011年至2016年间完成健康检查的韩国男性进行了一项队列研究。使用国际前列腺症状评分评估LUTS，其中评分≥8被定义为有意义的LUTS。根据男性的SUA水平（mg/dL）分为六组（<5.5、5.5−6.4、6.5−7.4、7.5−8.4、8.5−9.4和≥9.5）。在整个随访期间——总计358,982.6人年——13,424人出现有意义的LUTS（发病率为每1000人年37.3例）。多变量模型表明，与参考类别（<5.5 mg/dL）相比，最高水平的SUA（≥9.5 mg/dL）与有意义的LUTS的最低风险相关（调整后HR为0.77（95%CI 0.59−0.99））。在这个由中年男性组成的大型队列中，较高的SUA水平与LUTS风险降低相关。这一结果表明SUA在抑制LUTS方面的另一个潜在作用。需要进一步的研究来解释这种现象学关系的潜在生物学机制。
