ACS Appl Mater Interfaces. 2018 May 9;10(18):16113-16123. doi: 10.1021/acsami.8b01767. Epub 2018 Apr 25.
Developing efficient unimolecular visible light-emitting diode (LED) light photoinitiators (PIs) with photobleaching capability, which are essential for various biomedical applications and photopolymerization of thick materials, remains a great challenge. Herein, we demonstrate the synthesis of a series of novel PIs, containing coumarin moieties as chromophores and oxime ester groups as initiation functionalities and explore their structure-activity relationship. The investigated oxime esters can effectively induce acrylates and thiol-based click photopolymerization under 450 nm visible LED light irradiation. The initiator O-3 exhibited excellent photobleaching capability and enabled photopolymerization of thick materials (∼4.8 mm). The efficient unimolecular photobleachable initiators show great potential in dental materials and 3D printings.
开发具有光漂白能力的高效单分子可见光发光二极管 (LED) 光引发剂 (PI) 对于各种生物医学应用和厚材料的光聚合至关重要，但这仍然是一个巨大的挑战。在此，我们展示了一系列新型 PI 的合成，其中包含香豆素部分作为发色团和肟酯基团作为引发官能团，并探讨了它们的结构-活性关系。所研究的肟酯可以在 450nm 可见光 LED 光照射下有效引发丙烯酸酯和硫醇基点击光聚合。引发剂 O-3 表现出优异的光漂白能力，并能够实现厚材料（约 4.8mm）的光聚合。高效单分子可光漂白引发剂在牙科材料和 3D 打印中有很大的应用潜力。
