a Department of Immunochemistry , University Hospital and Faculty of Medicine in Pilsen , Czech Republic.
b Department of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen , Charles University , Czech Republic.
Syst Biol Reprod Med. 2018 Jun;64(3):220-223. doi: 10.1080/19396368.2018.1450906. Epub 2018 Mar 29.
Anti-Müllerian hormone (AMH), insulin-like growth factor 1 (IGF1) and leptin are produced in the granulosa cells of follicles and play an important role in the growth and maturation of follicles. The aim of our study was to monitor AMH, IGF1 and leptin levels in a group of healthy women and compare them to a group of women with fertility disorders. The second aim was the evaluation of biomarker levels in relation to the identified cause of infertility. Totally, 146 females were enrolled into our study. Seventy-two healthy controls and seventy-four females with fertility disorders were divided into four subgroups: anovulation, endometriosis, fallopian tube damage, unknown reason. IGF1 was the only biomarker with significantly lower levels throughout the entire group with fertility disorders. We did not identify any statistically significant differences for AMH and leptin. Regarding subgroups, significant differences were only observed in the group of anovulatory women. AMH and leptin showed higher levels while IGF1 showed lower levels. In conclusion, levels of AMH, IGF1 and leptin found in follicular fluid are sensitive markers for anovulatory fertility disorders. AMH, IGF1 and leptin levels in follicular fluid have no relation to the fertility disorders caused by endometriosis, fallopian tube damage or disorders with unknown etiology.
AMH: anti-Müllerian hormone; IGF1: insulin-like growth factor 1; PCOS: polycystic ovary syndrome.
抗苗勒管激素（AMH）、胰岛素样生长因子 1（IGF1）和瘦素均由卵泡颗粒细胞产生，在卵泡的生长和成熟中发挥重要作用。本研究旨在监测一组健康女性和一组生育障碍女性的 AMH、IGF1 和瘦素水平，并比较两者。其次，评估生物标志物水平与不孕原因之间的关系。共纳入 146 名女性进行研究。72 名健康对照组和 74 名生育障碍女性分为 4 个亚组：排卵障碍、子宫内膜异位症、输卵管损伤、不明原因。整个生育障碍组中，只有 IGF1 是唯一水平显著降低的生物标志物。我们未发现 AMH 和瘦素存在任何统计学差异。对于亚组，仅在排卵障碍女性组中观察到显著差异。AMH 和瘦素水平升高，而 IGF1 水平降低。总之，卵泡液中 AMH、IGF1 和瘦素的水平是排卵障碍性生育障碍的敏感标志物。卵泡液中 AMH、IGF1 和瘦素的水平与由子宫内膜异位症、输卵管损伤或不明原因引起的生育障碍无关。
AMH：抗苗勒管激素；IGF1：胰岛素样生长因子 1；PCOS：多囊卵巢综合征。
