镉处理小鼠中红细胞金属硫蛋白的合成与降解

Synthesis and degradation of erythrocyte metallothionein in cadmium-administered mice.

作者信息

Tanaka K, Min K, Onosaka S, Fukuhara C

机构信息

Department of Nutrition, Kobe-Gakuin University, Japan.

出版信息

Experientia Suppl. 1987;52:525-32. doi: 10.1007/978-3-0348-6784-9_53.

DOI:10.1007/978-3-0348-6784-9_53

PMID:2959544

Abstract

The origin of erythrocyte metallothionein (MT) in cadmium (Cd) administered mice and its fate were studied in connection with erythrocyte kinetics. It was shown that Cd-MT in the erythrocyte is synthesized in the precursor cells of the erythropoietic tissues, and Cd-MT containing erythrocytes come into the circulation after maturation. In regard to the degradation, it was found that Cd-MT is stable in the erythrocyte, but decomposed in the spleen or liver with the breakdown of erythrocyte when its life span is over.

摘要

结合红细胞动力学研究了给镉（Cd）小鼠注射后红细胞金属硫蛋白（MT）的起源及其归宿。结果表明，红细胞中的镉 - 金属硫蛋白是在造血组织的前体细胞中合成的，含镉 - 金属硫蛋白的红细胞成熟后进入循环。关于其降解，发现镉 - 金属硫蛋白在红细胞中稳定，但当红细胞寿命结束时，随着红细胞在脾脏或肝脏中被破坏而分解。