大鼠肠道对镉和无机汞的吸收：金属硫蛋白无主要作用。

Intestinal absorption of cadmium and inorganic mercury in the rat: no major involvement of metallothionein.

作者信息

Piotrowski J K, Szymańska J A, Kaszper B W, Skrzypińska-Gawrysiak M, Brzeźnicki S

机构信息

Department of Toxicological Chemistry, Medical Academy, Lódź, Poland.

出版信息

Experientia Suppl. 1987;52:639-46. doi: 10.1007/978-3-0348-6784-9_68.

DOI:10.1007/978-3-0348-6784-9_68

PMID:2959557

Abstract

The intestinal absorption of cadmium and inorganic mercury was studied in adult rats, administered the metal salts intragastrically or parenterally in repeated or single doses. The intestines contained only small proportion of the body burden; no major change was found in the intestinal level of metallothionein, copper and zinc. Therefore, no major role can be ascribed to intestinal metallothionein in limiting absorption of high oral doses of cadmium and mercury.

摘要

通过给成年大鼠经胃内或非经胃肠道重复或单次给予金属盐，研究了镉和无机汞的肠道吸收情况。肠道中仅含有少量的体内负荷；金属硫蛋白、铜和锌的肠道水平未发现重大变化。因此，肠道金属硫蛋白在限制高口服剂量镉和汞的吸收方面不能被认为起主要作用。