Freitas-Junior Ruffo, Martins Edesio, Metran-Nascente Cristiane, Carvalho Angela Assis, Silva Marilceia Ferreira da, Soares Leonardo Ribeiro, Ximenes Carlos Alberto
Program of Mastology, Federal University of Goias Arthesanal Pharmacia Department of Radiology, Federal University of Goias, Goiânia, GO, Brazil.
Medicine (Baltimore). 2018 Mar;97(13):e0261. doi: 10.1097/MD.0000000000010261.
This study was conducted within the Goias Mastology Research Network. To verify the possibility of diminishing pain, and discomfort during the mammography using analgesic administration.
Randomized, double-blinded, placebo controlled trial, testing paracetamol to diminish the pain, and discomfort during mammography. Three hundred patients who came for screening mammography were randomized for this study. A questionnaire with 2 parts was used: the first had questions that concerned the patient identification, and factors related to the pain during mammography; and the second asked about the scale of discomfort (no discomfort; uncomfortable; very uncomfortable; intolerable), and the pain (analogical linear scale) during the mammography. Each patient received 1000 mg of paracetamol, or placebo. Afterwards each patient filled out the second part of the questionnaire. Six patients were excluded from the analysis; this resulted in 149 in the paracetamol group, and 145 in the placebo group.
The 2 groups were homogenous concerning the mean of the ages, weight, height, and breast size. The mean of the pain was 3.5 in the paracetamol, and 2.8 in the placebo group (P = .12). There were fewer women experiencing mild pain in the paracetamol group when compared with those in placebo group (relative risk [RR] 0.76, confidence interval [CI] 95% 0.52-0.98). There was no significant difference between the 2 groups, according to the degrees of discomfort (P = .69).
The use of paracetamol can reduces the mild pain for women undergoing mammography.
本研究在戈亚斯乳腺病研究网络内进行。旨在验证通过给予镇痛药来减轻乳房X光检查期间疼痛和不适的可能性。
随机、双盲、安慰剂对照试验，测试对乙酰氨基酚减轻乳房X光检查期间的疼痛和不适。300名前来进行乳房X光筛查的患者被随机纳入本研究。使用一份包含两部分的问卷：第一部分有关于患者识别以及与乳房X光检查期间疼痛相关因素的问题；第二部分询问乳房X光检查期间的不适程度（无不适；不舒服；非常不舒服；无法忍受）和疼痛程度（视觉模拟线性量表）。每位患者接受1000毫克对乙酰氨基酚或安慰剂。之后每位患者填写问卷的第二部分。6名患者被排除在分析之外；这导致对乙酰氨基酚组有149名患者，安慰剂组有145名患者。
两组在年龄、体重、身高和乳房大小的均值方面具有同质性。对乙酰氨基酚组的疼痛均值为3.5，安慰剂组为2.8（P = 0.12）。与安慰剂组相比，对乙酰氨基酚组经历轻度疼痛的女性较少（相对危险度[RR] 0.76，95%置信区间[CI] 0.52 - 0.98）。根据不适程度，两组之间无显著差异（P = 0.69）。
使用对乙酰氨基酚可减轻接受乳房X光检查女性的轻度疼痛。
