Department of Anatomy, MTA-PTE PACAP Research Team, Neuroscience Centre, University of Pecs Medical School, 7624 Pécs, Hungary.
Int J Mol Sci. 2018 Mar 29;19(4):1020. doi: 10.3390/ijms19041020.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with widespread occurrence and diverse biological effects. Among its several different effects, of special importance is the action of PACAP on neuronal proliferation, differentiation and migration, and neuroprotection. The neuroprotective mechanism of PACAP is both direct and indirect, via neuronal and non-neuronal cells. Several research groups have performed transcriptomic and proteomic analysis on PACAP-mediated genes and proteins. Hundreds of proteins have been described as being involved in the PACAP-mediated neuroprotection. In the present review we summarize the few currently available transcriptomic data potentially leading to the proteomic changes in neuronal development and protection. Proteomic studies focusing on the neuroprotective role of PACAP are also reviewed and discussed in light of the most intriguing and promising effect of this neuropeptide, which may possibly have future therapeutic potential.
垂体腺苷酸环化酶激活肽（PACAP）是一种具有广泛发生和多种生物学效应的神经肽。在其几种不同的作用中，特别重要的是 PACAP 对神经元增殖、分化和迁移以及神经保护的作用。PACAP 的神经保护机制是直接和间接的，通过神经元和非神经元细胞。几个研究小组已经对 PACAP 介导的基因和蛋白质进行了转录组和蛋白质组分析。已经描述了数百种参与 PACAP 介导的神经保护的蛋白质。在本综述中，我们总结了目前少数可能导致神经元发育和保护中蛋白质组变化的可用转录组数据。还对专注于 PACAP 神经保护作用的蛋白质组学研究进行了综述和讨论，考虑到这种神经肽最有趣和有前途的作用，它可能具有未来的治疗潜力。
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