McInnes Steven J P, Macdonald Thomas J, Parkin Ivan P, Nann Thomas, Voelcker Nicolas H
Future Industries Institute, University of South Australia, Mawson Lakes 5095, Australia.
Department of Chemistry, University College London, London WC1E 6BT, UK.
Nanomaterials (Basel). 2018 Mar 29;8(4):205. doi: 10.3390/nano8040205.
This report describes the use of an electrospun composite of poly(ε-caprolactone) (PCL) fibers and porous silicon (pSi) nanoparticles (NPs) as an effective system for the tunable delivery of camptothecin (CPT), a small therapeutic molecule. Both materials are biodegradable, abundant, low-cost, and most importantly, have no known cytotoxic effects. The composites were treated with and without sodium hydroxide (NaOH) to investigate the wettability of the porous network for drug release and cell viability measurements. CPT release and subsequent cell viability was also investigated. We observed that the cell death rate was not only affected by the addition of our CPT carrier, pSi, but also by increasing the rate of dissolution via treatment with NaOH. This is the first example of loading pSi NPs as a therapeutics nanocarrier into electronspun PCL fibers and this system opens up new possibilities for the delivery of molecular therapeutics.
本报告描述了使用聚（ε-己内酯）（PCL）纤维与多孔硅（pSi）纳米颗粒（NPs）的电纺复合材料作为一种有效的系统，用于可调谐递送喜树碱（CPT），一种小分子治疗药物。这两种材料都是可生物降解的、丰富的、低成本的，并且最重要的是，没有已知的细胞毒性作用。对复合材料进行了有无氢氧化钠（NaOH）处理，以研究多孔网络对药物释放和细胞活力测量的润湿性。还研究了CPT释放及随后的细胞活力。我们观察到，细胞死亡率不仅受到我们的CPT载体pSi添加的影响，还受到通过NaOH处理提高溶解速率的影响。这是将pSi NPs作为治疗性纳米载体加载到电纺PCL纤维中的首个实例，该系统为分子治疗药物的递送开辟了新的可能性。
