Unterweger Christine, Ruczizka Ursula, Spergser Joachim, Baums Christoph Georg, Hennig-Pauka Isabel
University Clinics for Swine, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Institute of Microbiology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Pathogens. 2018 Mar 29;7(2):34. doi: 10.3390/pathogens7020034.
In newborn piglets treatment with long-acting ceftiofur is a common approach to reduce losses due to streptococcal diseases on farms, even if problems start after weaning. The purpose of this study was to examine the influence of a single early-life treatment on colonization, transmission, immunoreaction, and drug resistance over an observation period of 14 weeks. In a farm with a history of streptococcal disease and isolation of a 7 +, A+ isolate from diseased piglets, half of each litter was treated with a long-acting ceftiofur on day 1. -isolates were profiled and serum samples were tested for opsonizing antibodies. Treated and untreated pigs did not differ according to average daily weight gains, -isolation rates and level of opsonizing antibodies. Although the invasive 7 strain was not detected in a single piglet over 14 weeks, all animals developed bactericidal activity. No resistance to ceftiofur, but resistance to tetracyclins (100%), and trimethoprim/sulfamethoxazole (53%) was shown. Our results indicate that early treatment with ceftiofur does not prevent colonization and transmission of or the induction of bactericidal humoral immunity in nursery and fattening pigs. The necessity of continuous usage should be reconsidered.
在新生仔猪中，使用长效头孢噻呋进行治疗是减少农场因链球菌疾病造成损失的常用方法，即便问题在断奶后才出现。本研究的目的是在14周的观察期内，检验单次早期治疗对定植、传播、免疫反应和耐药性的影响。在一个有链球菌疾病病史且从患病仔猪中分离出7 +、A+菌株的农场中，每窝仔猪的一半在第1天接受长效头孢噻呋治疗。对分离菌株进行分析，并检测血清样本中的调理素抗体。治疗组和未治疗组仔猪在平均日增重、分离率和调理素抗体水平方面没有差异。尽管在14周内未在任何一头仔猪中检测到侵袭性7型菌株，但所有动物都产生了杀菌活性。未显示对头孢噻呋有耐药性，但对四环素（100%）和甲氧苄啶/磺胺甲恶唑（53%）有耐药性。我们的结果表明，早期使用头孢噻呋治疗并不能预防保育猪和育肥猪中7型菌株的定植和传播，也不能诱导杀菌性体液免疫。应重新考虑持续使用的必要性。
