To Evaluate the Efficacy of Topical Propolis in the Management of Symptomatic Oral Lichen Planus: A Randomized Controlled Trial.

INTRODUCTION

Lichen planus (LP) is a chronic inflammatory, autoimmune, mucocutaneous disease of unknown etiology. The first line of treatment for oral LP (OLP) has been corticosteroids, but because of their adverse effects, alternative therapeutic approaches are being carried out, of which the recent natural alternative is propolis.

AIM

This study aims to evaluate the efficacy of topical propolis in the management of OLP.

MATERIALS AND METHODS

The research group consisted of 27 patients diagnosed with symptomatic OLP, among which 15 patients were in the control group and the rest 12 were in the study group. The patients in the control group received triamcinolone acetonide 0.1% (topical application) while the patients in the study group received propolis gel. Both the groups were evaluated for pain and erythema at baseline (1 visit), first follow-up (7 day), and second follow-up (14 day) using numerical rating scale and modified oral mucositis index.

RESULTS

The patients in both the study and control groups showed a statistically significant reduction ( = 0.000 for the study group and = 0.000 for the control group) in pain and erythema scores from baseline to second follow-up visit. However, on comparison of the reduction in pain and erythema scores between the two groups, the difference was found to be statistically insignificant ( = 0.255).

STATISTICAL ANALYSIS USED

Chi-square and Cramer's V test were used.

CONCLUSION

The topical propolis was found to be of comparative effectiveness with respect to triamcinolone acetonide 0.1% in the management of OLP.