Joshy Athira, Doggalli Nagabhushana, Patil Karthikeya, Kulkarni P K
Department of Oral Medicine and Radiology, JSS Dental College and Hospital, Jagadguru Sri Shivarathreeshwara University, Mysore, Karnataka, India.
Department of Pharmaceutics JSS College of Pharmacy, Mysore, Karnataka, India.
Contemp Clin Dent. 2018 Jan-Mar;9(1):65-71. doi: 10.4103/ccd.ccd_751_17.
Lichen planus (LP) is a chronic inflammatory, autoimmune, mucocutaneous disease of unknown etiology. The first line of treatment for oral LP (OLP) has been corticosteroids, but because of their adverse effects, alternative therapeutic approaches are being carried out, of which the recent natural alternative is propolis.
This study aims to evaluate the efficacy of topical propolis in the management of OLP.
The research group consisted of 27 patients diagnosed with symptomatic OLP, among which 15 patients were in the control group and the rest 12 were in the study group. The patients in the control group received triamcinolone acetonide 0.1% (topical application) while the patients in the study group received propolis gel. Both the groups were evaluated for pain and erythema at baseline (1 visit), first follow-up (7 day), and second follow-up (14 day) using numerical rating scale and modified oral mucositis index.
The patients in both the study and control groups showed a statistically significant reduction ( = 0.000 for the study group and = 0.000 for the control group) in pain and erythema scores from baseline to second follow-up visit. However, on comparison of the reduction in pain and erythema scores between the two groups, the difference was found to be statistically insignificant ( = 0.255).
Chi-square and Cramer's V test were used.
The topical propolis was found to be of comparative effectiveness with respect to triamcinolone acetonide 0.1% in the management of OLP.
扁平苔藓（LP）是一种病因不明的慢性炎症性自身免疫性黏膜皮肤疾病。口服扁平苔藓（OLP）的一线治疗方法一直是使用皮质类固醇，但由于其副作用，正在开展替代治疗方法，其中最近的天然替代物是蜂胶。
本研究旨在评估局部应用蜂胶治疗OLP的疗效。
研究组由27例诊断为有症状OLP的患者组成，其中15例在对照组，其余12例在研究组。对照组患者接受0.1%曲安奈德（局部应用），而研究组患者接受蜂胶凝胶。两组患者在基线（第1次就诊）、首次随访（第7天）和第二次随访（第14天）时使用数字评分量表和改良口腔黏膜炎指数评估疼痛和红斑情况。
研究组和对照组患者从基线到第二次随访时疼痛和红斑评分均有统计学意义的降低（研究组P = 0.000，对照组P = 0.000）。然而，比较两组疼痛和红斑评分的降低情况时，发现差异无统计学意义（P = 0.255）。
采用卡方检验和克莱默V检验。
在OLP的治疗中，发现局部应用蜂胶与0.1%曲安奈德效果相当。
