Steinman L
Stanford University School of Medicine, California 94305.
Riv Neurol. 1987 May-Jun;57(3):173-4.
Treatment of experimental allergic encephalomyelitis with monoclonal antibodies to products of immune response genes and to surface markers on T cells was reviewed. Both anti Ia therapy and anti T4 therapy can reverse ongoing paralysis, and block subsequent relapses. The appearance of T4 cells and Ia antigens in relapse was demonstrated. The prospects for human therapy with chimeric human-mouse immunoglobulins and isotypic variants was discussed, with particular attention to the immunotherapy of multiple sclerosis.
综述了用针对免疫反应基因产物和T细胞表面标志物的单克隆抗体治疗实验性变应性脑脊髓炎的情况。抗Ia治疗和抗T4治疗均可逆转进行性麻痹，并阻止随后的复发。已证实在复发时有T4细胞和Ia抗原出现。讨论了用人-鼠嵌合免疫球蛋白和同型变体进行人体治疗的前景，尤其关注了多发性硬化症的免疫治疗。
