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实验性变应性脑脊髓炎：用一种识别辅助性T细胞的单克隆抗体在体内成功治疗

Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells.

作者信息

Brostoff S W, Mason D W

出版信息

J Immunol. 1984 Oct;133(4):1938-42.

PMID:6236260
Abstract

Monoclonal antibody W3/25, which recognizes rat T helper cells, was injected i.p. or i.v. into Lewis rats with clinical signs of experimental allergic encephalomyelitis (EAE). This treatment, which was given 12 or 13 days after inducing EAE by the injection of purified myelin basic protein, significantly affected the course of the disease in that treated animals recovered, on the average, in 2 days, whereas control animals exhibited signs of EAE for a minimum of 4 days. Two pan-T cell monoclonal antibodies given in similar dosage failed to affect the course of the disease.

摘要

识别大鼠T辅助细胞的单克隆抗体W3/25，经腹腔或静脉注射到出现实验性变态反应性脑脊髓炎（EAE）临床症状的Lewis大鼠体内。在通过注射纯化的髓鞘碱性蛋白诱导EAE 12或13天后进行这种治疗，显著影响了疾病进程，接受治疗的动物平均在2天内康复，而对照动物至少4天表现出EAE症状。以类似剂量给予的两种泛T细胞单克隆抗体未能影响疾病进程。

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