Hota Susy S, Poutanen Susan M
Department of Infection Prevention and Control, University Health Network, Toronto, Canada.
Department of Medicine, University of Toronto, Toronto, Canada.
Open Forum Infect Dis. 2018 Feb 23;5(3):ofy045. doi: 10.1093/ofid/ofy045. eCollection 2018 Mar.
infection, a common hospital-associated infection, is a gastrointestinal illness that becomes recurrent in about 25% of infected patients. Fecal microbiota transplantation (FMT) is increasingly supported by clinical trials as an effective treatment for recurrent infection, but a number of questions remain about how it can be optimally performed. In this Perspective, we discuss controversies in FMT methodologies and reporting within randomized controlled trials, all of which may influence clinical outcomes in treated patients. Finally, we focus on the question of whether single vs multiple FMTs are necessary to achieve favorable outcomes for the treatment of recurrent infection, postulating on why there may be an association between number of FMTs and clinical effectiveness.
艰难梭菌感染是一种常见的医院获得性感染，是一种胃肠道疾病，约25%的感染患者会复发。粪便微生物群移植（FMT）作为复发性艰难梭菌感染的一种有效治疗方法，越来越受到临床试验的支持，但关于如何以最佳方式进行FMT仍存在许多问题。在这篇观点文章中，我们讨论了FMT方法学以及随机对照试验报告中的争议，所有这些都可能影响接受治疗患者的临床结果。最后，我们关注单次FMT与多次FMT对于复发性艰难梭菌感染治疗取得良好疗效是否必要的问题，并推测FMT次数与临床疗效之间可能存在关联的原因。
