Amer Kamil M, Mohamed Sana, Amer Rami, Chaudhry Ahmed, Winters Brian, Abraham John A
Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, 140 Bergen St., Newark, New Jersey 07103.
Temple University School of Podiatric Medicine, Philadelphia, Pennsylvania.
J Orthop Res. 2018 Sep;36(9):2554-2561. doi: 10.1002/jor.23902. Epub 2018 May 23.
Although certainly not the first line treatment for plantar fibromas, surgical resection is a treatment option for some patients with have failed exhaustive non-surgical treatment. The use of topical Mitomycin C has been recently shown to reduce the recurrence rate of other fibrous lesions. The purpose of this study was to determine the impact of topical application of Mitomycin C on recurrence rate of plantar fibromas. A retrospective analysis was done from a prospectively gathered database with a total 50 consecutive patients over a 16-month study period. The control group (n = 29) consisted of patients who underwent only surgical resection, while the study group (n = 21) consisted of patients who underwent surgical resection with adjuvant therapy using Mitomycin C. The primary endpoint was local recurrence after the procedure. Secondary end points included complications and toxicity associated with this medication. No patients were lost to follow up. Of the 29 patients in the control group, there were 17 patients (17/29, 58.6%) had recurrence of the plantar fibroma at a mean follow-up of 9.1 months. In contrast, in the experimental study group, all patients were free from local recurrence. No complications or side effects were associated with Mitomycin C use. The results demonstrate that the topical application of Mitomycin C to the tumor bed after surgical resection of plantar fibromas reduced the recurrence rate. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2554-2561, 2018.
虽然手术切除肯定不是足底纤维瘤的一线治疗方法，但对于一些经过彻底非手术治疗失败的患者来说，它是一种治疗选择。最近研究表明，局部使用丝裂霉素C可降低其他纤维性病变的复发率。本研究的目的是确定局部应用丝裂霉素C对足底纤维瘤复发率的影响。在一项为期16个月的前瞻性收集数据库中，对连续50例患者进行了回顾性分析。对照组（n = 29）由仅接受手术切除的患者组成，而研究组（n = 21）由接受手术切除并辅以丝裂霉素C治疗的患者组成。主要终点是术后局部复发。次要终点包括与此药物相关的并发症和毒性。没有患者失访。对照组的29例患者中，有17例（17/29，58.6%）在平均随访9.1个月时出现足底纤维瘤复发。相比之下，在实验研究组中，所有患者均无局部复发。使用丝裂霉素C未出现并发症或副作用。结果表明，足底纤维瘤手术切除后在肿瘤床局部应用丝裂霉素C可降低复发率。© 2018年骨科研究协会。由威利期刊公司出版。《矫形外科学研究》36:2554 - 2561，2018年。
