Resident Physician, Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, NJ.
Research Assistant, Department of Orthopaedic Surgery, Rutgers New Jersey Medical School, Newark, NJ.
J Foot Ankle Surg. 2020 Sep-Oct;59(5):903-908. doi: 10.1053/j.jfas.2020.03.007. Epub 2020 May 29.
Ganglion cysts are among the most common benign soft tissue masses. Although surgery has been shown to be effective, ∼12% to 42% of cases with long-term follow-up have been reported to recur. The purpose of this study was to determine the impact of the topical application of mitomycin C used as an adjuvant to surgery on recurrence rate of ganglion cysts. A retrospective analysis was done on all patients surgically treated by 1 surgeon for ganglion cysts. The primary end point was local recurrence after the procedure, determined clinically and by ultrasound. Secondary outcomes included wound complication rate, adverse effects, and overall patient satisfaction. A total of 98 consecutive patients were included in this study and assigned to a study group in a nonrandomized manner. The control group (n = 52) consisted of patients who underwent surgical resection only. The study group (n = 46) consisted of patients who underwent surgical resection with application of topical mitomycin C. No patients were lost to follow-up. Of the 52 patients in the control group, 13 (25.0%) had recurrence of the ganglion cyst. In contrast, in the experimental study group, 2 patients (4.3%) had a recurrence. There was no difference in superficial wound infections between the 2 groups. In this study, we found that the use of topical mitomycin C as an adjuvant to surgical resection significantly reduced the recurrence rate. Wound infection and overall nonrecurrence complication rates were similar to those of other studies.
神经腱鞘囊肿是最常见的良性软组织肿块之一。虽然手术已被证明是有效的，但在长期随访中，有报道称约 12%至 42%的病例会复发。本研究旨在确定作为手术辅助剂的丝裂霉素 C 局部应用对神经腱鞘囊肿复发率的影响。对 1 位外科医生手术治疗的所有神经腱鞘囊肿患者进行了回顾性分析。主要终点是术后临床和超声确定的局部复发。次要结局包括伤口并发症发生率、不良反应和整体患者满意度。这项研究共纳入 98 例连续患者，并以非随机方式分为研究组和对照组。对照组（n=52）为仅接受手术切除的患者。研究组（n=46）为接受手术切除加局部应用丝裂霉素 C 的患者。无患者失访。在对照组的 52 例患者中，有 13 例（25.0%）出现神经腱鞘囊肿复发。相比之下，在实验组中，有 2 例（4.3%）出现复发。两组的浅表伤口感染无差异。在这项研究中，我们发现局部应用丝裂霉素 C 作为手术切除的辅助剂显著降低了复发率。伤口感染和整体非复发并发症发生率与其他研究相似。
