Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.
Unit of Allergology, Immunology, Rheumatology, Campus Bio-Medico University, Rome, Italy.
Int Wound J. 2018 Jun;15(3):424-428. doi: 10.1111/iwj.12882. Epub 2018 Mar 30.
Patients with systemic sclerosis (SSc) are at a high risk of the development of ischaemic digital ulcers (DUs) that can be complicated with infections, gangrene, and osteomyelitis. The aim of this study is to evaluate the role of endostatin in scleroderma DUs.In total, 90 SSc patients were enrolled in this study. Serum endostatin levels and DU assessment were determined in all SSc patients. The serum levels of endostatin significantly increased with progression of capillaroscopic damage (P < .01). The serum levels of endostatin are significantly (P < .05) higher in SSc patients with new DUs than in SSc patients without new DUs (127 ± 31.1 ng/mL vs 116.3 ± 39.7 ng/mL). The Receiver Operating Characteristic (ROC) curves demonstrated good accuracy of new DU prediction for the serum level of endostatin (0.70, P < .01 [95% confidence interval (CI) 0.59-0.81]). Using a cut-off value of 116 ng/mL, the odds ratio was 2.609 (CI 1.075-6.330, P < .05). The serum levels of endostatin are significantly (P < .01) higher in SSc patients with infected DUs than in SSc patients without infected DUs (139.2 [114.6-340.91] ng/mL vs 117.5 [64.3-163.9] ng/mL). Serum levels of endostatin are higher in patients with DUs, especially in those with infected DUs.
系统性硬化症（SSc）患者发生缺血性指溃疡（DU）的风险很高，这些溃疡可能会并发感染、坏疽和骨髓炎。本研究旨在评估内皮抑素在硬皮病 DU 中的作用。
本研究共纳入 90 例 SSc 患者。所有 SSc 患者均进行血清内皮抑素水平和 DU 评估。毛细血管镜损伤进展时，血清内皮抑素水平显著升高（P<0.01）。与无新发 DU 的 SSc 患者相比，新发 DU 的 SSc 患者血清内皮抑素水平显著升高（P<0.05）（127±31.1ng/mL 比 116.3±39.7ng/mL）。受试者工作特征（ROC）曲线表明，血清内皮抑素水平对新发 DU 的预测具有良好的准确性（0.70，P<0.01[95%置信区间（CI）0.59-0.81]）。使用 116ng/mL 的截断值，比值比为 2.609（CI 1.075-6.330，P<0.05）。感染性 DU 的 SSc 患者血清内皮抑素水平明显高于无感染性 DU 的 SSc 患者（139.2[114.6-340.91]ng/mL 比 117.5[64.3-163.9]ng/mL）。血清内皮抑素水平在 DU 患者中较高，尤其是感染性 DU 患者。
