Opt Lett. 2018 Apr 1;43(7):1582-1585. doi: 10.1364/OL.43.001582.
Viscosity and elasticity are closely related to the physiological characteristics of biological tissues. This Letter reports a simultaneous quantitative measurement of these parameters realized with the laser speckle contrast imaging method. The propagation of a Rayleigh wave induced by an acoustic speaker is traced, and the frequency-dependent velocity dispersion is extracted with the frequency-wavenumber spectrum analysis method. The viscosity and elasticity moduli of oil-in-gelatin tissue-mimicking phantoms are calculated by fitting the dispersion curves to the Voigt model. The method is validated by comparing it with the results obtained by using a conventional mechanical rheometer.
粘度和弹性与生物组织的生理特性密切相关。本研究采用激光散斑对比成像方法，实现了对这些参数的同时定量测量。通过追踪由声扬声器产生的瑞利波的传播，利用频波数谱分析方法提取了频率相关的速度弥散。通过将色散曲线拟合到Voigt 模型，计算了油凝胶组织模拟体的粘度和弹性模量。通过与传统的机械流变仪的结果进行比较，验证了该方法的有效性。
