Opt Lett. 2022 May 1;47(9):2214-2217. doi: 10.1364/OL.451464.
Viscoelasticity is an important diagnostic parameter to investigate physiological dysfunctions in biological tissues. This Letter reports the quantification of viscoelastic parameters by Rayleigh wave tracing on the surface of tissue-mimicking phantoms using holographic imaging. The Rayleigh wave is induced by an electromechanical actuator on the surface of oil-in-gelatin phantoms and a biological tissue sample followed by holographic imaging and reconstruction of the wave. The frequency-dependent velocity dispersion is fitted to a Voigt model for the quantification of viscous and elastic moduli. The viscoelastic parameters calculated by the proposed method are validated by comparing the results from a conventional mechanical rheometer.
粘弹性是研究生物组织生理功能障碍的一个重要诊断参数。本研究报告了使用全息成像技术在油凝胶体仿生模型和生物组织样本表面通过瑞利波追踪对粘弹性参数进行定量分析的方法。瑞利波由置于油凝胶体仿生模型表面的机电致动器产生，然后对波进行全息成像和重建。对速度频散进行粘弹Voigt 模型拟合，以定量计算粘性和弹性模量。通过与传统机械流变仪的结果进行比较，验证了所提出方法计算得到的粘弹性参数的准确性。
