Elce Ausilia, Nigro Ersilia, Gelzo Monica, Iacotucci Paola, Carnovale Vincenzo, Liguori Renato, Izzo Viviana, Corso Gaetano, Castaldo Giuseppe, Daniele Aurora, Zarrilli Federica
Dipartimento di Scienze Umanistiche, Università Telematica Pegaso, Naples 80132, Italy.
Dipartimento di Medicina e Scienze, della Salute, Università del Molise, Campobasso, 86100, Italy.
Clin Respir J. 2018 Jul;12(7):2228-2234. doi: 10.1111/crj.12796. Epub 2018 Apr 30.
Cystic fibrosis (CF) is the most common inherited, life limiting condition among Caucasians. No healing therapy is currently available for patients with CF. The aim of the study was to define clinical, anthropometric and biochemical effects of regular, supervised physical exercise in a large cohort of patients with CF.
Fifty-nine adult patients with CF that performed regularly supervised physical exercise in the last 3 years in comparison to 59 sex and age matched sedentary patients with CF were included in the study.
Physical exercise had significantly beneficial effects on: (a) FEV1% decline; (b) anthropometric parameters (lower number of cases with altered BMI, waist and arm circumferences); (c) lipid and glucose metabolism; (d) vitamin D serum levels. Of course, some of this improvement may be because of the better adherence to therapy typical of patients with CF that perform physical activity.
Such clinical and metabolic effects make supervised physical activity one of the hubs in managing patients with CF.
囊性纤维化（CF）是白种人中最常见的遗传性、危及生命的疾病。目前尚无针对CF患者的治愈性疗法。本研究的目的是确定在一大群CF患者中进行定期、有监督的体育锻炼的临床、人体测量学和生化影响。
本研究纳入了59例在过去3年中进行定期有监督体育锻炼的成年CF患者，并与59例年龄和性别匹配的久坐不动的CF患者进行比较。
体育锻炼对以下方面有显著有益影响：（a）第一秒用力呼气容积（FEV1）百分比下降；（b）人体测量学参数（体重指数、腰围和臂围改变的病例数减少）；（c）脂质和葡萄糖代谢；（d）血清维生素D水平。当然，这种改善部分可能是因为进行体育活动的CF患者对治疗的依从性更好。
这些临床和代谢效应使有监督的体育活动成为管理CF患者的核心措施之一。
