2006 - 2012年北京市房山区唇腭裂患病率

Prevalence of Cleft Lip/Palate in the Fangshan District of Beijing, 2006-2012.

作者信息

Yang Yanfen, Liu Hui, Ma Ruixin, Jin Lei

机构信息

1 Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

2 Maternal and Child Health Hospital, Fangshan District, Beijing, China.

出版信息

Cleft Palate Craniofac J. 2018 Oct;55(9):1296-1301. doi: 10.1177/1055665618767115. Epub 2018 Mar 30.

DOI:10.1177/1055665618767115

PMID:29601215

Abstract

OBJECTIVE

To estimate the cleft lip with or without cleft palate (CL/P) prevalence among births between 2006 and 2012 in Fangshan district of Beijing, China.

DESIGN

Surveillance data analysis.

SETTING

All hospitals that provide obstetric services in the district.

PATIENTS

The CL/P cases presented for this report were from 13 weeks' gestation to 7 days postpartum.

MAIN OUTCOME MEASURES

The CL/P prevalence was defined as the number of cases per 10 000 births, including live births and stillbirths at 28 weeks' gestation or beyond.

RESULTS

The overall CL/P prevalence was 18.9 (95% confidence interval [CI]: 15.1-22.7) per 10 000 births. From 2006 to 2012, the CL/P prevalence was 19.3, 20.2, 10.9, 16.1, 17.5, 25.4, and 22.3 per 10 000 births; annually, no significant change was noted ( P = .311). The prevalence of cleft palate, cleft lip, and cleft lip and palate were 3.4 (95% CI: 2.0-5.4), 6.2 (95% CI: 4.2-8.8), and 9.4 (95% CI: 6.9-12.4) per 10 000 births, respectively. The CL/P prevalence among the nonpermanent residents (31.4 per 10 000 births) was 2.31 times that of permanent residents (13.6 per 10 000 births). Among nonpermanent residents, the CL/P prevalence showed an upward trend over the study period ( P = .036), that increased from 38.8 (95% CI: 16.5-76.6) per 10 000 births in 2006 to 54.6 (95% CI: 25.7-100.4) per 10 000 births in 2012.

CONCLUSIONS

The overall CL/P prevalence was stable in the Fangshan district. However, the CL/P prevalence of the nonpermanent residents increased significantly.

摘要

目的

估算2006年至2012年中国北京市房山区出生婴儿中唇裂伴或不伴腭裂（CL/P）的患病率。

设计

监测数据分析。

地点

该地区所有提供产科服务的医院。

研究对象

本报告中的CL/P病例为妊娠13周后至产后7天的病例。

主要观察指标

CL/P患病率定义为每10000例出生婴儿中的病例数，包括妊娠28周及以后的活产和死产。

结果

CL/P总体患病率为每10000例出生婴儿中有18.9例（95%置信区间[CI]：15.1 - 22.7）。2006年至2012年，CL/P患病率分别为每10000例出生婴儿中有19.3例、20.2例、10.9例、16.1例、17.5例、25.4例和22.3例；每年均未观察到显著变化（P = 0.311）。单纯腭裂、单纯唇裂以及唇腭裂的患病率分别为每10000例出生婴儿中有3.4例（95%CI：2.0 - 5.4）、6.2例（95%CI：4.2 - 8.8）和9.4例（95%CI：6.9 - 12.4）。非户籍居民的CL/P患病率（每10000例出生婴儿中有31.4例）是户籍居民（每(10000例出生婴儿中有13.6例）的2.31倍。在非户籍居民中，CL/P患病率在研究期间呈上升趋势（P = 0.036），从2006年的每10000例出生婴儿中有38.8例（(95%CI：16.5 - 76.6）增至2012年的每10000例出生婴儿中有54.6例（95%CI：25.7 - 100.4）。