新型结核疫苗的现状、挑战和未来发展。
The current status, challenges, and future developments of new tuberculosis vaccines.
机构信息
a Army Tuberculosis Prevention and Control Key Laboratory/Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute for Tuberculosis Research , Haidian District, Beijing , China.
出版信息
Hum Vaccin Immunother. 2018 Jul 3;14(7):1697-1716. doi: 10.1080/21645515.2018.1458806. Epub 2018 May 14.
Abstract
Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guérin (BCG), is ineffective for prevention of pulmonary TB in adults. Therefore, it is very important to develop novel vaccines for TB prevention and control. This literature review provides an overview of the innate and adaptive immune response during M. tuberculosis infection, and presents current developments and challenges to novel TB vaccines. A comprehensive understanding of vaccines in preclinical and clinical studies provides extensive insight for the development of safer and more efficient vaccines, and may inspire new ideas for TB prevention and treatment.
摘要
结核分枝杆菌复合体引起结核病（TB），是全球十大死因之一。结核病导致的死亡人数超过与耐多药（MDR）HIV 株相关的合并感染。疫苗在传染病的预防和控制中起着关键作用。不幸的是，唯一获得许可的预防结核病的疫苗，卡介苗（BCG），对预防成人肺结核无效。因此，开发新型结核病疫苗非常重要。本文综述了结核分枝杆菌感染期间固有和适应性免疫反应，并介绍了新型结核疫苗的最新进展和挑战。全面了解临床前和临床研究中的疫苗为开发更安全、更有效的疫苗提供了广泛的见解，并可能为结核病的预防和治疗提供新的思路。
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