Department of Radiology, University Hospital, LMU Munich.
German Center for Cardiovascular Disease Research (DZHK e.V.), Munich.
J Hypertens. 2018 Jul;36(7):1555-1562. doi: 10.1097/HJH.0000000000001741.
To compare the correlations of MRI-derived adipose tissue measurements and anthropometric markers, respectively, with prevalent hypertension in a community-based sample, free of clinical cardiovascular disease.
MRI-derived adipose tissue measurements were obtained in 345 participants (143 women; age 39-73 years) of the KORA FF4 survey from Southern Germany using a 3-Tesla machine and included total adipose tissue (TAT), visceral adipose tissue (VAT), subcutaneous adipose tissue (SCAT), hepatic fat fraction (HFF), pancreatic fat fraction (PFF) as well as pericardial adipose tissue (PAT). In addition, the anthropometric markers body mass index, waist circumference, hip circumference, waist-hip ratio (WHR) and waist-height ratio (WHtR) as well as blood pressure measurements were obtained.
The prevalence of hypertension was 33.6% (women: 28%, men: 38%). VAT and PAT had the highest area under the curve (AUC) values for identifying individuals with prevalent hypertension (AUC: 0.75; 0.73, respectively), whereas WHtR and waist circumference were best performing anthropometric markers (AUC: 0.72; 0.70, respectively). A 1SD increment of TAT was associated with the highest odd for hypertension in the age-adjusted and sex-adjusted model (OR = 2.20, 95% CI 1.67-2.91, P < 0.001) and in the fully adjusted model (OR = 1.97, 95% CI 1.45-2.66, P < 0.001). TAT was the only MRI-derived adipose tissue measurement that was associated with hypertension independently of the best performing anthropometric marker waist circumference in the fully adjusted model (OR = 1.93, 95% CI 1.00-3.72, P = 0.049).
MRI-derived adipose tissue measurements perform similarly in identifying prevalent hypertension compared with anthropometric markers. Especially, TAT, VAT and PAT as well as WHtR and waist circumference were highly correlated with prevalent hypertension.
在一个无临床心血管疾病的社区样本中，分别比较磁共振成像（MRI）衍生的脂肪组织测量值与人体测量标志物与现患高血压的相关性。
使用 3 特斯拉机器在德国南部的 KORA FF4 调查中对 345 名参与者（女性 143 名；年龄 39-73 岁）进行 MRI 衍生的脂肪组织测量，包括总脂肪组织（TAT）、内脏脂肪组织（VAT）、皮下脂肪组织（SCAT）、肝脂肪分数（HFF）、胰腺脂肪分数（PFF）以及心包脂肪组织（PAT）。此外，还获得了人体测量标志物体重指数、腰围、臀围、腰臀比（WHR）和腰高比（WHtR）以及血压测量值。
高血压患病率为 33.6%（女性：28%，男性：38%）。VAT 和 PAT 对识别现患高血压患者的曲线下面积（AUC）值最高（AUC：0.75；0.73），而 WHtR 和腰围是表现最佳的人体测量标志物（AUC：0.72；0.70）。TAT 增加 1SD 与年龄和性别调整模型中高血压的最高比值比（OR=2.20，95%CI 1.67-2.91，P<0.001）和完全调整模型（OR=1.97，95%CI 1.45-2.66，P<0.001）中高血压的最高比值比相关。在完全调整模型中，TAT 是唯一与高血压相关的 MRI 衍生脂肪组织测量值，与表现最佳的人体测量标志物腰围独立相关（OR=1.93，95%CI 1.00-3.72，P=0.049）。
与人体测量标志物相比，MRI 衍生的脂肪组织测量值在识别现患高血压方面表现相似。特别是 TAT、VAT 和 PAT 以及 WHtR 和腰围与现患高血压高度相关。
