Faculty of Medical Sciences, Department of Genetics, University of Kragujevac, 34000 Kragujevac, Serbia.
Faculty of Medical Sciences, Department of Microbiology and immunology, Center for Molecular Medicine and Stem Cell Research, University of Kragujevac, 34000 Kragujevac, Serbia.
Int J Mol Sci. 2018 Mar 30;19(4):1039. doi: 10.3390/ijms19041039.
Spinal cord injury (SCI), a serious public health issue, most likely occurs in previously healthy young adults. Current therapeutic strategies for SCI includes surgical decompression and pharmacotherapy, however, there is still no gold standard for the treatment of this devastating condition. Inefficiency and adverse effects of standard therapy indicate that novel therapeutic strategies are required. Because of their neuroregenerative and neuroprotective properties, stem cells are a promising tool for the treatment of SCI. Herein, we summarize and discuss the promising therapeutic potential of human embryonic stem cells (hESC), induced pluripotent stem cells (iPSC) and ependymal stem/progenitor cells (epSPC) for SCI.
脊髓损伤(SCI)是一个严重的公共卫生问题,很可能发生在以前健康的年轻成年人中。目前 SCI 的治疗策略包括手术减压和药物治疗,但对于这种破坏性疾病仍然没有金标准的治疗方法。标准治疗的低效性和不良反应表明需要新的治疗策略。由于其具有神经再生和神经保护特性,干细胞是治疗 SCI 的一种有前途的工具。本文总结和讨论了人胚胎干细胞(hESC)、诱导多能干细胞(iPSC)和室管膜干细胞/祖细胞(epSPC)治疗 SCI 的有前途的治疗潜力。