载脂蛋白 E ε4 等位基因在阿尔茨海默病谱系中淀粉样 β 阳性受试者中的流行率。
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.
机构信息
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden.
Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.
出版信息
Alzheimers Dement. 2018 Jul;14(7):913-924. doi: 10.1016/j.jalz.2018.02.009. Epub 2018 Mar 28.
INTRODUCTION
Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology.
METHODS
We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location.
RESULTS
The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education.
DISCUSSION
The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.
简介
载脂蛋白 E（APOE）ε4 是阿尔茨海默病（AD）的主要遗传风险因素，但由于早期研究不要求淀粉样蛋白 β（Aβ）病理学的生物标志物证据，因此其患病率尚不清楚。
方法
我们纳入了 3451 名 Aβ+受试者（853 例 AD 型痴呆，1810 例轻度认知障碍，788 例认知正常）。使用广义估计方程模型评估 APOE ε4 与年龄、性别、教育程度和地理位置的相关性。
结果
AD 型痴呆中 APOE ε4 的患病率为 66%，轻度认知障碍中为 64%，认知正常中为 51%，在 Aβ+认知正常和 Aβ+轻度认知障碍中随年龄增长而降低（P<0.05），但在 Aβ+AD 痴呆中则没有（P=0.66）。患病率在北欧最高，但不受性别或教育程度的影响。
讨论
AD 中 APOE ε4 的患病率高于之前不要求存在 Aβ 病理学的研究。此外，我们的结果突出了与年龄和地理位置相关的疾病异质性。
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