More Than : Genetic Predictors in Alzheimer Disease in ε3 Carriers.
作者信息
Peters Nils, Unschuld Paul G
机构信息
Department of Neurology and Stroke Center, Klinik Hirslanden, Zürich, Switzerland.
University of Basel, Switzerland.
出版信息
Neurol Genet. 2025 Jul 21;11(4):e200284. doi: 10.1212/NXG.0000000000200284. eCollection 2025 Aug.
Abstract
摘要
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本文引用的文献
1
Polygenic risk for Alzheimer's disease is associated with neuroaxonal damage before onset of clinical symptoms.阿尔茨海默病的多基因风险与临床症状出现前的神经轴突损伤有关。
Alzheimers Dement (Amst). 2024 Jan 9;16(1):e12504. doi: 10.1002/dad2.12504. eCollection 2024 Jan-Mar.
2
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.载脂蛋白 E ε4 等位基因在阿尔茨海默病谱系中淀粉样 β 阳性受试者中的流行率。
Alzheimers Dement. 2018 Jul;14(7):913-924. doi: 10.1016/j.jalz.2018.02.009. Epub 2018 Mar 28.
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TREM2 variants in Alzheimer's disease.TREM2 变体在阿尔茨海默病中的作用。
N Engl J Med. 2013 Jan 10;368(2):117-27. doi: 10.1056/NEJMoa1211851. Epub 2012 Nov 14.
4
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.人载脂蛋白 E 异构体差异调节脑淀粉样β肽清除。
Sci Transl Med. 2011 Jun 29;3(89):89ra57. doi: 10.1126/scitranslmed.3002156.
5
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.阿尔茨海默病的早老素假说：功能丧失致病机制的证据
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):403-9. doi: 10.1073/pnas.0608332104. Epub 2006 Dec 29.
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