合成纳米纤维素的设计优化研究，评价与表面修饰作为一种有前途的生物医学应用的潜在生物材料。
A design optimization study on synthesized nanocrystalline cellulose, evaluation and surface modification as a potential biomaterial for prospective biomedical applications.
机构信息
Department of Chemistry, Kocaeli University, 41380 Kocaeli, Turkey.
Department of Chemistry, Kocaeli University, 41380 Kocaeli, Turkey.
出版信息
Int J Biol Macromol. 2018 Jul 15;114:536-546. doi: 10.1016/j.ijbiomac.2018.03.155. Epub 2018 Mar 27.
In the present study, nanocrystalline cellulose (NCC) was prepared via acid hydrolysis and synthesis parameters were optimized via response surface modelling with a determined maximum NCC yield of 43.8%. The optimized NCC sample was subsequently surface modified via epichlorohydrin-mediated amination forming aminated nanocrystalline cellulose (A-NCC) with an amine content calculated as 1500μmol/g. The average particle size and zeta potential were determined 100nm and 325nm for NCC and A-NCC, respectively. Structural properties were analyzed by FTIR, TEM and XRD techniques. The obtained A-NCC as final product depicted a pKa value of 10.86±0.07 demonstrating favourable protonation of amine groups at physiological pH allowing the material to be suitable for prospective application in drug delivery and tissue engineering.
在本研究中，通过酸水解制备了纳米纤维素（NCC），并通过响应面建模优化了合成参数，得到了最大 NCC 产率为 43.8%。随后，通过环氧氯丙烷介导的氨化对优化后的 NCC 样品进行表面改性，形成氨基纳米纤维素（A-NCC），其胺含量计算为 1500μmol/g。NCC 和 A-NCC 的平均粒径和zeta 电位分别为 100nm 和 325nm。通过 FTIR、TEM 和 XRD 技术分析了结构性能。最终产物 A-NCC 的 pKa 值为 10.86±0.07，表明在生理 pH 下胺基的质子化有利于质子化，使该材料适合于药物输送和组织工程的潜在应用。
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