Maternal, Fetal, Neonatal Institute, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Department of Nutritional Sciences Graduate Programs in Clinical Nutrition, School of Health Professions, Rutgers, The State University of New Jersey, Rutgers, New Jersey, USA.
Nutr Clin Pract. 2018 Oct;33(5):679-686. doi: 10.1002/ncp.10060. Epub 2018 Mar 30.
In premature infants, donor breast milk (DBM) is assumed to provide reduced nutrients vs. mother's own milk (MOM). This study examined calorie and protein delivery when very low birth weight infants were fed fortified MOM or DBM, with a known nutrient composition, relative to established nutrition recommendations and to determine if there were differences between the groups.
A retrospective medical record review was conducted in 29 very low birth weight infants receiving MOM or DBM. Nutrient content of human milk was measured using the Calais Analyzer. Added fortifiers feeding volume, and weight were collected to determine total daily calorie and protein intake.
145 days of enteral feedings among 29 infants were included, 78 (53.8%) from DBM and 67 (46.2%) from MOM. Mean daily fluid intake among infants receiving DBM was significantly higher when compared with MOM, 150.6 ± 7.6 mL/kg vs 146.8 ± 11.3 mL/kg (P = .016). DBM feedings provided 110.1 ± 9.0 kcals/kg/d vs 113.0 ± 21.0 kcals/kg/d from MOM feedings (P = .275). Mean protein intake was similar, 4.1 ± 0.5 g /kg/d on DBM days vs 4.0 ± 0.5 g kg/d on MOM days (P = .162). A total of 46 of 78 DBM days (59.0%) and 30 of 67 MOM days (44.8%) were below the minimum established calorie needs of 110 kcals/kg/day.
DBM provides comparable nutrient intake to MOM at a higher enteral feeding volume. However, both types of human milk failed to meet energy needs with standard fortification regimens.
在早产儿中，捐赠母乳（DBM）被认为提供的营养少于母亲自身的母乳（MOM）。本研究检测了强化 MOM 或 DBM 喂养极低出生体重儿时的热量和蛋白质输送情况，所使用的人乳具有已知的营养成分，并确定了两组之间是否存在差异。
对 29 名接受 MOM 或 DBM 的极低出生体重儿进行了回顾性病历审查。使用 Calais 分析仪测量人乳的营养成分。收集添加的强化剂喂养量和体重，以确定每日总热量和蛋白质摄入量。
纳入了 29 名婴儿的 145 天肠内喂养，78 名（53.8%）来自 DBM，67 名（46.2%）来自 MOM。与 MOM 相比，接受 DBM 的婴儿的每日液体摄入量明显更高，150.6±7.6 毫升/公斤/天比 146.8±11.3 毫升/公斤/天（P=.016）。DBM 喂养提供的热量分别为 110.1±9.0 kcal/kg/d，而 MOM 喂养提供的热量分别为 113.0±21.0 kcal/kg/d（P=.275）。平均蛋白质摄入量相似，DBM 喂养 4.1±0.5 克/公斤/天，MOM 喂养 4.0±0.5 克/公斤/天（P=.162）。DBM 喂养的 78 天中有 46 天（59.0%）和 MOM 喂养的 67 天中有 30 天（44.8%）低于 110 kcal/kg/天的最低设定热量需求。
DBM 以更高的肠内喂养量提供与 MOM 相当的营养摄入。然而，在标准强化方案下，这两种类型的人乳均未满足能量需求。
