Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Department of Pediatric and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Pediatr Blood Cancer. 2018 Jul;65(7):e27037. doi: 10.1002/pbc.27037. Epub 2018 Mar 30.
Pediatric head and neck malignancies are rare and only a few descriptive epidemiological studies have been published. Using unique nationwide registries, we report age-specific incidence rates of head and neck cancer (HNC) among children during four decades.
Data were obtained from the Danish Cancer Registry. We included children aged 0-14 years diagnosed between January 1, 1978 and December 31, 2014 with extra-orbital, nonskin and nonbone HNC. Patients were divided into nine groups in regard to tumor location: oral cavity, oropharynx, nasopharynx, hypopharynx, thyroid, major salivary glands, larynx, and middle ear. Based on the World Health Organization standard population and Danish age-specific population counts, age-adjusted incidence rates (AAIR) and average annual percentage change (AAPC) were calculated and examined for trends.
In total, 169 children (55.6% females) were registered with a malignant tumor in the head and neck region. The AAIR increased with an AAPC of 2.2% (95% CI, 0.8-3.7%). Females showed an AAIR of 0.54 per 100,000 person years compared to that of males, with 0.41 per 100,000 person years (P < 0.01). The AAIR was higher among children aged 10-14 years compared to 0-9-year-old children (P < 0.01). Based on morphology, a significant increase in AAIR was observed for sarcomas, with an increase of 0.16-0.27 per 100,000 person years (P < 0.05).
The incidence rate of pediatric HNC was higher among females and evidence of increasing rates was observed during 1978-2014, explained by an increase mainly in sarcomas.
儿科头颈部恶性肿瘤较为罕见，仅有少数描述性流行病学研究发表。我们利用独特的全国性登记处，报告了 40 年来儿童头颈部癌症（HNC）的年龄特异性发病率。
数据来自丹麦癌症登记处。我们纳入了 1978 年 1 月 1 日至 2014 年 12 月 31 日期间诊断为眼眶外、非皮肤和非骨骼 HNC 的 0-14 岁儿童。根据肿瘤位置，患者被分为 9 组：口腔、口咽、鼻咽、下咽、甲状腺、大唾液腺、喉和中耳。基于世界卫生组织标准人口和丹麦年龄特异性人口计数，计算了年龄调整发病率（AAIR）和平均年百分比变化（AAPC），并检查了趋势。
共有 169 名儿童（55.6%为女性）被确诊患有头颈部恶性肿瘤。AAIR 呈上升趋势，AAPC 为 2.2%（95%CI，0.8-3.7%）。女性的 AAIR 为 0.54/10 万人年，而男性为 0.41/10 万人年（P<0.01）。10-14 岁儿童的 AAIR 高于 0-9 岁儿童（P<0.01）。基于形态学，肉瘤的 AAIR 显著增加，每年增加 0.16-0.27/10 万人年（P<0.05）。
儿科 HNC 的发病率在女性中较高，1978-2014 年期间观察到发病率呈上升趋势，这主要归因于肉瘤的增加。
