Schmidt Jensen Jakob, Grønhøj Christian, Ruud Kjær Eva Kristine, Charabi Birgitte Wittenborg, von Buchwald Christian, Hjuler Thomas
Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Int J Pediatr Otorhinolaryngol. 2019 Dec;127:109648. doi: 10.1016/j.ijporl.2019.109648. Epub 2019 Aug 23.
The survival among children with cancer has improved considerably the past decades. Consequently, more children are at risk of second primary cancers (SPC). This study aimed to investigate the incidence of SPC among pediatric head and neck cancer (HNC) patients.
Data on children aged 0-17 years registered with a HNC in the Danish Registry of Childhood Cancer and the Danish National Patient Registry during the period 1980-2014 was obtained. SPC was defined as registration with any second malignancy that was not simultaneous with the first primary cancer (FPC) or a relapse hereof. All information was validated through review of medical charts. Standardized incidence rates (SIR) were calculated using the average incidence of all cancers in the general population of Denmark during the study period as reference.
Among 234 pediatric HNC patients, six patients (four females) were registered with a SPC (2.6%), corresponding to an overall SIR of 4.8. No patients were diagnosed with more than one SPC. The median age at FPC and SPC was 15.2 years (range 9-16 years) and 35.0 years (range 19-41 years). The most common tumor histology and location among the patients with SPC was nasopharyngeal lymphoepithelial carcinoma for FPC and basal cell carcinoma of the skin for SPC.
During 1980-2014 we identified six cases of SPC among 234 pediatric head and neck cancer patients in Denmark, corresponding to an overall SIR of 4.8.
在过去几十年中，癌症患儿的生存率有了显著提高。因此，更多的儿童面临患第二原发性癌症（SPC）的风险。本研究旨在调查儿童头颈癌（HNC）患者中SPC的发病率。
获取了1980年至2014年期间在丹麦儿童癌症登记处和丹麦国家患者登记处登记的0至17岁患有HNC的儿童的数据。SPC被定义为登记患有任何与第一原发性癌症（FPC）不同时发生或其复发的第二恶性肿瘤。所有信息均通过病历审查进行了验证。使用研究期间丹麦普通人群中所有癌症的平均发病率作为参考，计算标准化发病率（SIR）。
在234例儿童HNC患者中，有6例患者（4名女性）登记患有SPC（2.6%），总体SIR为4.8。没有患者被诊断出患有不止一种SPC。FPC和SPC的中位年龄分别为15.2岁（范围9至16岁）和35.0岁（范围19至41岁）。SPC患者中最常见的肿瘤组织学类型和部位，FPC为鼻咽淋巴上皮癌，SPC为皮肤基底细胞癌。
在1980年至2014年期间，我们在丹麦的234例儿童头颈癌患者中发现了6例SPC病例，总体SIR为4.8。
