糖尿病中亚氨酸限制的代谢调控。
Metabolic Regulation of Methionine Restriction in Diabetes.
机构信息
Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, China.
Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, China.
出版信息
Mol Nutr Food Res. 2018 May;62(10):e1700951. doi: 10.1002/mnfr.201700951.
Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction (MR) and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.
虽然膳食蛋氨酸限制对衰老生理学和与氧化应激相关疾病的影响已经得到了研究，但蛋氨酸限制（MR）与代谢紊乱发展之间的关系尚未得到广泛探索。本文综述了膳食蛋氨酸限制改善胰岛素抵抗、葡萄糖稳态、氧化应激、脂代谢、磷酸戊糖途径（PPP）和炎症的可能作用，重点介绍了糖尿病中纤维母细胞生长因子 21 和蛋白磷酸酶 2A 信号和自噬。缺乏蛋氨酸的饮食可能是糖尿病患者的一种有用的营养策略。
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