Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2020 Jun 9;11:365. doi: 10.3389/fendo.2020.00365. eCollection 2020.
The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.
戊糖磷酸途径（PPP）从葡萄糖 6-磷酸（G6P）分支，生成 NADPH 和核糖 5-磷酸（R5P），并将碳分流回糖酵解或糖异生途径。PPP 已被证明是细胞还原-氧化（redox）平衡和生物合成的主要调节剂。据报道，PPP 中的酶在许多人类疾病中发挥重要作用。在这篇综述中，我们将讨论 PPP 在 2 型糖尿病和癌症中的作用。
