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技术说明:建立双散射质子束系统蒙特卡罗模拟模型的方法。

Technical Note: An approach to building a Monte Carlo simulation model for a double scattering proton beam system.

机构信息

Department of Radiation Oncology, University Hospitals, Cleveland Medical Center, Cleveland, 44106, OH, USA.

出版信息

Med Phys. 2018 Jun;45(6):2660-2666. doi: 10.1002/mp.12895. Epub 2018 Apr 18.

Abstract

PURPOSE

The purpose of this study was to demonstrate and develop a Monte Carlo (MC) simulation model for a passive double scattering compact proton therapy system based on limited information of the mechanical components.

METHOD

We built a virtual machine source model (VMSM) which included a detailed definition of each beam-modifying component in the nozzle. Conceptually, it is similar to the conventional virtual analytical source model (VASM), except that the numerical machine nozzle or beamline is constructed in the VMSM, whereas in the VASM analytical parameters characterizing the energy spectrum and source fluence distribution are sought. All major beam shaping components were included in the VMSM and the model simulates interactions of the beam with a rotating range modulation wheel (RMW) combined with the beam current modulation. The RMWs, the first and second scatterer in the system were generated and tuned to reproduce measurement data as closely as possible. To validate the model, we compared the percent depth dose curves, spread out Bragg peaks (SOBPs) and lateral profiles against measured commissioning beam data.

RESULTS

The agreement of beam range between the MC calculation and measurement was within 1 mm for all beam options. The distal-falloff length was in good agreement as well (<1 mm for the large and deep groups, <1.5 mm for the small group). Agreement to within 2.5 mm of measured SOBP widths was obtained for all MC calculations. For lateral profiles, differences were found to be less than 2 mm.

CONCLUSIONS

We demonstrated that with limited geometrical information it is possible to build an acceptable source model for MC simulations of a passive double scattering compact proton therapy system. The agreement between the measurements and the MC model provides validation for use of the model for further studies of the dosimetric effects in patient treatments.

摘要

目的

本研究旨在展示和开发一种基于机械部件有限信息的被动式双散射紧凑型质子治疗系统的蒙特卡罗(MC)模拟模型。

方法

我们构建了一个虚拟机器源模型(VMSM),其中包括喷嘴中每个光束修正组件的详细定义。从概念上讲,它类似于传统的虚拟分析源模型(VASM),但在 VMSM 中构建了数值机器喷嘴或光束线,而在 VASM 中则寻求描述能谱和源注量分布的分析参数。所有主要的光束成形组件都包含在 VMSM 中,该模型模拟了与旋转式调强轮(RMW)以及束流调制的相互作用。RMW、系统中的第一个和第二个散射体被生成并进行调整,以尽可能接近地再现测量数据。为了验证模型,我们将百分深度剂量曲线、扩展布拉格峰(SOBP)和侧向分布与测量的调试束数据进行了比较。

结果

对于所有束选项,MC 计算和测量的束射程之间的一致性在 1 毫米以内。远侧下降长度也非常吻合(大而深组<1 毫米,小组<1.5 毫米)。对于所有 MC 计算,都可以获得与测量 SOBP 宽度相差 2.5 毫米以内的结果。对于侧向分布,差异小于 2 毫米。

结论

我们证明,即使只有有限的几何信息,也可以为被动式双散射紧凑型质子治疗系统的 MC 模拟构建可接受的源模型。测量值与 MC 模型之间的一致性为模型在进一步研究患者治疗中的剂量学效应方面的应用提供了验证。

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