Ojeda Javier, Mieres Marcelo, Soto Francisco, Arnes Verónica, Paredes Enrique, Navarrete María
Veterinary Clinical Science, Universidad Austral de Chile, Valdivia, Chile.
Department of Animal Pathology, Universidad Austral de Chile, Valdivia, Chile.
J Vet Intern Med. 2018 May;32(3):1172-1177. doi: 10.1111/jvim.15125. Epub 2018 Mar 31.
Primary nasal canine transmissible venereal tumor (CTVT) without genital affection is uncommon. The aim of this report was to describe the primary nasal CTVT findings and CT staging in 4 dogs with different cytological phenotypes. Three male dogs and 1 bitch were evaluated for their chronic histories of sneezing, snoring, mucopurulent nasal discharge and nasal deformation. Cytological examination of nasal secretions suggested CTVT, confirmed by histopathological examination and LINE-1/c-myc. Males had the plasmacytoid phenotype of CTVT, and the bitch had the lymphocytoid phenotype. CTVT were staged based on the CT findings using modified Adams staging system. The bitch was classified as stage 1, 2 males were classified as stage 3 and 1 male as stage 4. All dogs had a complete tumoral remission after chemotherapy. Plasmacytoid phenotype was identified in cases with most important damage of the nasal cavity. However, the cytological type did not affect the response to chemotherapy.
原发性鼻腔犬传染性性病肿瘤（CTVT）而无生殖器受累情况并不常见。本报告的目的是描述4只具有不同细胞学表型的犬的原发性鼻腔CTVT的表现及CT分期。对3只公犬和1只母犬进行了评估，它们均有打喷嚏、打鼾、黏液脓性鼻分泌物及鼻变形的慢性病史。鼻分泌物的细胞学检查提示为CTVT，经组织病理学检查及LINE-1/c-myc证实。公犬具有CTVT的浆细胞样表型，母犬具有淋巴细胞样表型。根据CT表现使用改良的亚当斯分期系统对CTVT进行分期。母犬被分类为1期，2只公犬被分类为3期，1只公犬被分类为4期。所有犬在化疗后肿瘤均完全缓解。浆细胞样表型在鼻腔损伤最严重的病例中被发现。然而，细胞学类型并不影响对化疗的反应。
