Papazoglou L G, Koutinas A F, Plevraki A G, Tontis D
Clinic of Surgery, Department of Clinical Studies, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.
J Vet Med A Physiol Pathol Clin Med. 2001 Sep;48(7):391-400. doi: 10.1046/j.1439-0442.2001.00361.x.
The medical records of six dogs with primary intranasal transmissible venereal tumour (TVT) were reviewed. Epistaxis (4/6), serosangineous nasal discharge (2/6), oronasal fistulae (2/6), facial swelling (1/6) and submandibular lymphadenopathy (3/6) due to reactive hyperplasia (2/3) and metastasis (1/3) were the most common complaints and clinical findings. Diagnosis was made by rhinoscopy and confirmed by cytology and histopathology in five dogs and by cytology only in one dog. The microscopic appearance of the tumours with both diagnostic techniques was typical of TVT. Four cases were treated effectively with four to five weekly cycles of vincristine monotherapy that resulted in complete resolution of TVT masses in approximately 1 month. One case was resistant to this kind of treatment and another one was lost to follow-up.
回顾了6只患有原发性鼻内传染性性病肿瘤（TVT）犬的病历。鼻出血（4/6）、血清血性鼻分泌物（2/6）、口鼻瘘（2/6）、面部肿胀（1/6）以及因反应性增生（2/3）和转移（1/3）导致的下颌下淋巴结病（3/6）是最常见的主诉和临床发现。通过鼻镜检查进行诊断，5只犬经细胞学和组织病理学确诊，1只犬仅经细胞学确诊。两种诊断技术下肿瘤的显微镜表现均为典型的TVT。4例采用长春新碱单一疗法，每周进行4至5个周期治疗，约1个月内TVT肿块完全消退，治疗效果良好。1例对这种治疗耐药，另1例失访。
