土耳其精神科门诊患者间歇性爆发障碍的流行情况及其临床相关性。
Prevalence and clinical correlates of intermittent explosive disorder in Turkish psychiatric outpatients.
机构信息
Osmaniye Government Hospital, Department of Psychiatry, Osmaniye, Turkey.
Cukurova University, Department of Psychiatry, Adana, Turkey.
出版信息
Compr Psychiatry. 2018 May;83:64-70. doi: 10.1016/j.comppsych.2018.03.003. Epub 2018 Mar 18.
OBJECTIVE
Intermittent explosive disorder (IED) is defined as the failure to resist aggressive impulses resulting in repeated acts of verbal and/or physical aggression. Although it is frequently encountered in clinical psychiatric practice, there is a paucity of data concerning IED in the scientific literature both internationally and in Turkey. The aim of this study was to evaluate the prevalence of IED and associated sociodemographic and clinical features in a clinical setting.
METHODS
A total of 406 patients who were referred to our psychiatry outpatient clinic for the first time in a six-month period were included in the study. The diagnosis of IED was made using both Diagnostic and Statistical Manual of Mental Disorders 4th edition (DSM-IV) and DSM-5 criteria. Axis I disorder and personality disorder diagnoses were made according to DSM-5 criteria. Diagnoses were based on information from the Structured Clinical Interview for DSM-IV (SCID I) and the Structured Clinical Interview for DSM-IV personality disorders (SCID II), Symptom Checklist-90 (SCL-90), Wender Utah Rating Scale, Adult Attention Deficit Hyperactivity Disorder (ADHD) DSM-IV Based Diagnostic Screening and Rating Scale, a clinical interview conducted by the researcher, and a sociodemographic data form. In addition, participants were administered the Buss-Perry Aggression Scale and Barratt Impulsiveness Scale Version 11 (BIS-11) to assess aggression and impulsivity.
RESULTS
Lifetime and 12-month prevalence of IED according to DSM-5 were 16.7% and 11.3%, respectively. Mean age at onset was 16.4 years. The prevalence of lifetime IED was 3.8 times higher in males than females (95% CI = 1.9-7.5); twice as high in individuals living in rural areas compared to those living in urban centers (95% CI = 1.1-3.7); 2.7 times higher among those with lifetime suicide attempt versus those without (95% CI = 1.3-5.6); 4.5 times higher in those with lifetime self-injurious behavior compared to those without (95% CI = 2.3-8.7); and 3 times higher in individuals reporting aggression/anger problems in the family compared to those without (95% CI = 1.5-5.9). The prevalences of childhood ADHD, conduct disorder, and oppositional defiant disorder were significantly higher in the IED group.
CONCLUSION
The result of the current study has revealed that approximately one-sixth of respondents experienced lifetime IED according to DSM-5 diagnostic criteria. Statistically significant sociodemographic correlates of IED include gender, urbanicity, history of suicide attempt, history of self-injurious behavior, and family history of aggression/anger problems.
目的
间歇性爆发障碍(IED)被定义为无法抗拒攻击冲动,导致反复出现言语和/或身体攻击行为。尽管在临床精神科实践中经常遇到,但无论是在国际上还是在土耳其,科学文献中关于 IED 的数据都很少。本研究的目的是在临床环境中评估 IED 的患病率以及相关的社会人口学和临床特征。
方法
在六个月的时间内,我们首次将 406 名患者纳入研究。使用《精神障碍诊断与统计手册》第 4 版(DSM-IV)和 DSM-5 标准诊断 IED。根据 DSM-5 标准诊断轴 I 障碍和人格障碍。诊断基于 DSM-IV 结构临床访谈(SCID I)和 DSM-IV 人格障碍结构临床访谈(SCID II)、症状清单-90(SCL-90)、Wender 犹他州评定量表、成人注意缺陷多动障碍(ADHD)DSM-IV 基于诊断筛查和评定量表、研究者进行的临床访谈以及社会人口学数据表格中的信息。此外,还使用 Buss-Perry 攻击性量表和 Barratt 冲动量表第 11 版(BIS-11)评估参与者的攻击性和冲动性。
结果
根据 DSM-5,终身和 12 个月 IED 的患病率分别为 16.7%和 11.3%。发病年龄的平均值为 16.4 岁。与女性相比,男性的终身 IED 患病率高 3.8 倍(95%可信区间[CI]:1.9-7.5);与居住在城市中心的人相比,居住在农村地区的人高 2 倍(95%CI:1.1-3.7);与没有自杀未遂史的人相比,有自杀未遂史的人高 2.7 倍(95%CI:1.3-5.6);与没有自残行为史的人相比,有自残行为史的人高 4.5 倍(95%CI:2.3-8.7);与报告家庭中有攻击性/愤怒问题的人相比,没有家庭中有攻击性/愤怒问题的人高 3 倍(95%CI:1.5-5.9)。IED 组儿童期 ADHD、品行障碍和对立违抗性障碍的患病率明显更高。
结论
目前的研究结果表明,根据 DSM-5 诊断标准,大约六分之一的受访者经历过终身 IED。IED 的统计学显著社会人口学相关因素包括性别、城市性、自杀未遂史、自残行为史和家庭攻击性/愤怒问题史。