Department of Education and Treatment of Obesity and Metabolic Disorders, University of Medical Sciences in Poznań, Szamarzewskiego Str. 84, 60-569 Poznań, Poland.
Department of Pulmonology, Allergology and Respiratory Oncology, University of Medical Sciences in Poznań, Szamarzewskiego Str. 84, 60-569 Poznań, Poland.
Biomed Pharmacother. 2018 Jun;102:792-797. doi: 10.1016/j.biopha.2018.03.131. Epub 2018 Apr 5.
Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function.
Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen activator inhibitor 1 (PAI-1), as well as total antioxidant status (TAS) were quantified at baseline and the end of study.
At the end of study SI (p = 0.01), hsCRP (p < 0.001, PAI-1 (p < 0.001), LDL cholesterol (p < 0.001), and TAS (p < 0.01) were reduced in the GE-supplemented group, but not in the placebo group.
This randomized, double-blind, placebo-controlled trial demonstrates that supplementation with GE favorably modifies endothelial biomarkers associated with cardiovascular risk and suggests that GE can be used to suppress chronic inflammation in obese individuals.
大蒜具有一系列与人类健康相关的作用。然而，其对肥胖个体内皮的影响尚不清楚。本研究旨在确定大蒜提取物（GE）对动脉僵硬和内皮功能标志物的影响。
本研究纳入了 92 名受试者。将参与者随机分配，每天服用 400mg 的 GE 或安慰剂，持续 3 个月。在基线和研究结束时，定量检测动脉僵硬指数（SI）和内皮功能标志物，如高敏 C 反应蛋白（hsCRP）、胆固醇（总胆固醇、LDL、HDL）、甘油三酯和纤溶酶原激活物抑制剂 1（PAI-1）以及总抗氧化状态（TAS）。
研究结束时，GE 补充组的 SI（p=0.01）、hsCRP（p<0.001）、PAI-1（p<0.001）、LDL 胆固醇（p<0.001）和 TAS（p<0.01）降低，但安慰剂组没有。
这项随机、双盲、安慰剂对照试验表明，GE 的补充可以改善与心血管风险相关的内皮生物标志物，并表明 GE 可用于抑制肥胖个体的慢性炎症。
