Wilkin J K, Hazelrigg E J
Department of Pharmacology, Medical College of Virginia, Richmond.
Clin Pharmacol Ther. 1987 Nov;42(5):582-7. doi: 10.1038/clpt.1987.200.
The effect of naltrexone vs. placebo on alcohol-provoked flushing was studied in 20 healthy subjects of Oriental ancestry and 20 healthy white subjects. The intensity of the flushing reactions was assessed by two independent methods, the cutaneous perfusion index by laser Doppler velocimetry and the change in malar thermal circulation index by telethermometry. No effect of naltrexone on alcohol-provoked flushing was detected with either method in either racial group. The incidence of abdominal discomfort and nausea associated with naltrexone treatment was much greater among Orientals than whites.
在20名具有东方血统的健康受试者和20名健康白人受试者中研究了纳曲酮与安慰剂对酒精诱发脸红的影响。通过两种独立方法评估脸红反应的强度，即激光多普勒测速法测定的皮肤灌注指数和远红外温度计测定的颧部热循环指数变化。在两个种族组中，两种方法均未检测到纳曲酮对酒精诱发脸红有影响。与纳曲酮治疗相关的腹部不适和恶心的发生率在东方人中比在白人中高得多。
