Kokonozaki Maria, Kanellou Peggy, Pappa Constantine A, Vyzoukaki Rodanthi, Sarantoulaki Styliani, Stavroulaki Emilia, Kyriakaki Stavroula, Alegakis Athanasios, Boula Anna, Alexandrakis Michael G
Hematology Laboratory, University Hospital of Heraklion, Heraklion, Greece.
Hematology Department, University Hospital of Heraklion, Heraklion, Greece.
Crit Rev Oncog. 2017;22(3-4):255-262. doi: 10.1615/CritRevOncog.2018021355.
The FLT3-ligand is a molecule implicated in hematopoiesis. The aim of the present study was to detect any possible connections between serum levels of FLT3-L and multiple myeloma (MM) proliferation markers, such as serum levels of interleukin-6 (IL-6), B-cell activating factor (BAFF), beta-2 microglobulin (B2M), CRP and LDH, as well the percentage of bone marrow infiltration and the plasma cells' proliferation marker Ki-67 PI. We measured the above parameters in 58 patients with active MM. All circulating markers were significantly higher in MM patients compared to controls (p < 0.001 for all cases), and all values were increasing in parallel with disease stage (p < 0.001 for all cases). Positive correlations between FLT3-L were noted with serum levels of BAFF (p < 0.003), IL-6 (p < 0.002), CRP (p < 0.0001), LDH (p < 0.001), and BM Ki-67 PI (p = 0.012), whereas only trends of correlation were noted with the B2M value and the percentage of infiltration. It seems that the increased serum levels of circulating FLT3-L, in parallel with MM activity, reflect their increased presence in the bone marrow microenvironment, probably as an effect of increased angiogenesis and myelosuppression. Consequently, they are potential markers of disease activity.
FLT3配体是一种与造血作用有关的分子。本研究的目的是检测血清FLT3-L水平与多发性骨髓瘤（MM）增殖标志物之间的任何可能联系，这些标志物如血清白细胞介素-6（IL-6）、B细胞活化因子（BAFF）、β2微球蛋白（B2M）、CRP和LDH水平，以及骨髓浸润百分比和浆细胞增殖标志物Ki-67增殖指数（PI）。我们对58例活动性MM患者的上述参数进行了测量。与对照组相比，MM患者所有循环标志物均显著升高（所有病例p<0.001），且所有值均随疾病分期升高（所有病例p<0.001）。FLT3-L与BAFF血清水平（p<0.003）、IL-6（p<0.002）、CRP（p<0.0001）、LDH（p<0.001）和骨髓Ki-67 PI（p = 0.012）呈正相关，而与B2M值和浸润百分比仅呈相关趋势。似乎循环中FLT3-L血清水平升高与MM活性平行，反映了它们在骨髓微环境中存在增加，可能是血管生成增加和骨髓抑制的结果。因此，它们是疾病活性的潜在标志物。
