Rizkallah Raed, Hurt Myra M
Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, USA.
Crit Rev Oncog. 2017;22(1-2):109-129. doi: 10.1615/CritRevOncog.2017020959.
The multifunctional protein Yin Yang 1 (YY1) plays critical roles in tumorigenesis. YY1 has been shown to be involved in the development, progression, resistance, and invasiveness of many types of cancers. Today, the value of YY1 as a prognostic marker and as a potential target in cancer therapy is being explored by multiple research groups around the world. Over the past 25 years, we have accumulated a wealth of information about the wide-ranging biological functions of YY1 at the molecular, cellular, and organismal levels. However, our knowledge of how YY1 is regulated and what regulates it has lagged behind. In the past few years, there has been a significant increase in the research addressing this issue. In this review, we summarize and analyze recent findings about the regulation of YY1 at multiple levels. We emphasize the necessity for deeper insights into these regulatory mechanisms if YY1 is to find its way to the clinical setting.
多功能蛋白阴阳1（YY1）在肿瘤发生过程中发挥着关键作用。YY1已被证明参与多种癌症的发生、发展、耐药性及侵袭性。如今，全球多个研究团队正在探索YY1作为预后标志物以及癌症治疗潜在靶点的价值。在过去25年里，我们在分子、细胞和机体水平上积累了大量关于YY1广泛生物学功能的信息。然而，我们对YY1如何被调控以及由什么调控的了解却滞后了。在过去几年中，针对这一问题的研究有了显著增加。在本综述中，我们总结并分析了YY1在多个水平上调控的最新研究结果。我们强调，如果YY1要应用于临床，深入了解这些调控机制的必要性。
