Zhang Qiang, Stovall Daniel B, Inoue Kazushi, Sui Guangchao
Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Crit Rev Oncog. 2011;16(3-4):163-97. doi: 10.1615/critrevoncog.v16.i3-4.30.
Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological functions. YY1 either activates or represses gene transcription, depending on the stimuli received by the cells and its association with other cellular factors. Since its discovery, a biological role for YY1 in tumor development and progression has been suggested because of its regulatory activities toward multiple cancer-related proteins and signaling pathways and its overexpression in most cancers. In this review, we primarily focus on YY1 studies in cancer research, including the regulation of YY1 as a transcription factor, its activities independent of its DNA binding ability, the functions of its associated proteins, and mechanisms regulating YY1 expression and activities. We also discuss the correlation of YY1 expression with clinical outcomes of cancer patients and its target potential in cancer therapy. Although there is not a complete consensus about the role of YY1 in cancers based on its activities of regulating oncogene and tumor suppressor expression, most of the currently available evidence supports a proliferative or oncogenic role of YY1 in tumorigenesis.
阴阳1（YY1）是一种具有多样且复杂生物学功能的转录因子。YY1既可激活也可抑制基因转录，这取决于细胞所接收的刺激以及它与其他细胞因子的关联。自其被发现以来，由于YY1对多种癌症相关蛋白和信号通路具有调控活性且在大多数癌症中过度表达，因此有人提出YY1在肿瘤发生和发展中具有生物学作用。在本综述中，我们主要聚焦于YY1在癌症研究中的相关研究，包括作为转录因子的YY1的调控、其独立于DNA结合能力的活性、其相关蛋白的功能以及调控YY1表达和活性的机制。我们还讨论了YY1表达与癌症患者临床结局的相关性及其在癌症治疗中的靶向潜力。尽管基于YY1调控癌基因和肿瘤抑制因子表达的活性，对于其在癌症中的作用尚无完全一致的看法，但目前大多数现有证据支持YY1在肿瘤发生中具有增殖或致癌作用。
