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精神分裂症中动机和神经认知与功能的关系:一项元分析综述

The Relationship of Motivation and Neurocognition with Functionality in Schizophrenia: A Meta-analytic Review.

作者信息

Najas-Garcia Antonia, Gómez-Benito Juana, Huedo-Medina Tania B

机构信息

Department of Methodology of the Behavioral Sciences, University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.

Institute for Brain, Cognition, and Behavior (IR3C), University of Barcelona, Passeig Vall d'Hebron 171, 08035, Barcelona, Spain.

出版信息

Community Ment Health J. 2018 Oct;54(7):1019-1049. doi: 10.1007/s10597-018-0266-4. Epub 2018 Mar 31.

Abstract

The role that neurocognition plays in functionality in schizophrenia has been widely examined, although in recent years increasing attention has been paid to the influence of motivation instead. This study provides a review of the relationship of neurocognition and motivation with functionality in schizophrenia, taking into account objective/subjective functionality assessment, demographic variables, and the different terms used when referring to motivation. A search of electronic databases identified 34 studies that met the inclusion criteria for review. Correlation coefficients between motivation and functionality and between neurocognition and functionality were extracted. For a better understanding, potential moderator variables were also extracted. Meta-analysis showed that both motivation and neurocognition assessments were strongly associated with functioning, with correlations between motivation and functional outcomes being stronger. However, more than three-quarters of the variance in outcome remained unexplained by the moderating factors examined. The paper concludes with recommendations for clinical practice and future research.

摘要

尽管近年来人们越来越关注动机的影响,但神经认知在精神分裂症功能中所起的作用已得到广泛研究。本研究回顾了神经认知和动机与精神分裂症功能之间的关系,同时考虑了客观/主观功能评估、人口统计学变量以及提及动机时使用的不同术语。通过检索电子数据库,确定了34项符合纳入标准的研究进行综述。提取了动机与功能之间以及神经认知与功能之间的相关系数。为了更好地理解,还提取了潜在的调节变量。荟萃分析表明,动机评估和神经认知评估均与功能密切相关,动机与功能结果之间的相关性更强。然而,所研究的调节因素仍无法解释超过四分之三的结果差异。本文最后提出了临床实践和未来研究的建议。

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