Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Danish Cancer Society, Copenhagen, Denmark.
Department of Documentation & Quality, Danish Cancer Society, Copenhagen, Denmark.
Eur J Cancer. 2018 Nov;103:288-298. doi: 10.1016/j.ejca.2018.02.031. Epub 2018 Mar 29.
Tobacco smoking is a leading cause of cancer and the most preventable cause of cancer worldwide. The aim of this study was to quantify the proportion of the cancer burden in the Nordic countries linked to tobacco smoking and estimate the potential for cancer prevention by changes in smoking prevalence.
The Prevent macro-simulation model was used, estimating the future number of cancer cases in the Nordic countries over a 30-year period (2016-2045), for 13 cancer sites, under different scenarios of changing smoking prevalence, and compared to the projected number of cases if constant prevalence prevailed.
A total of 430,000 cancer cases, of the 2.2 million expected for the 13 studied cancer sites, could be avoided in the Nordic countries over the 30-year period if smoking was eliminated from 2016 onwards. If prevalence of smoking is reduced to 5% by year 2030 and to 2% by 2040, 230,000 cancer cases could be avoided. The largest proportion of cancers can be avoided in Denmark, where smoking prevalence is the highest, and similar to the prevalence in many European countries.
A large amount of cancers could be avoided in the Nordic countries if smoking prevalence was reduced. The results from this study can be used to understand the potential impact and significance of primary prevention programmes targeted towards reducing the prevalence of tobacco smoking in the Nordic countries.
吸烟是癌症的主要病因,也是全球范围内最可预防的癌症病因。本研究旨在量化与吸烟有关的癌症负担在北欧国家所占的比例,并评估通过改变吸烟流行率来预防癌症的潜力。
使用了 Prevent 宏观模拟模型,估算了未来 30 年内(2016 年至 2045 年)北欧国家 13 个癌症部位的癌症病例数,针对不同的吸烟流行率变化情景,并与如果流行率保持不变时预计的病例数进行了比较。
如果从 2016 年起消除吸烟,北欧国家在未来 30 年内可能会避免 220 万预计 13 个研究癌症部位的 230 万例癌症病例。如果到 2030 年将吸烟流行率降低到 5%,到 2040 年降低到 2%,则可以避免 230 万例癌症病例。在吸烟流行率最高的丹麦,可避免的癌症比例最大,与许多欧洲国家的流行率相似。
如果降低吸烟流行率,北欧国家可能会避免大量癌症病例。本研究的结果可用于了解有针对性地减少北欧国家吸烟流行率的初级预防方案的潜在影响和意义。