Andersson Therese M-L, Weiderpass Elisabete, Engholm Gerda, Lund Anne-Sofie Q, Olafsdottir Elinborg, Pukkala Eero, Stenbeck Magnus, Storm Hans
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Danish Cancer Society, Copenhagen, Denmark.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Eur J Cancer. 2017 Jul;79:106-118. doi: 10.1016/j.ejca.2017.03.028. Epub 2017 May 3.
Several types of cancers are causally linked to overweight and obesity, which are increasing in the Nordic countries. The aim of this study was to quantify the proportion of the cancer burden linked to overweight and obesity in the Nordic countries and estimate the potential for cancer prevention.
Under different prevalence scenarios of overweight and obesity, the number of cancer cases in the Nordic countries in the next 30 years (i.e. 2016-2045) was estimated for 13 cancer sites and compared to the projected number of cancer cases if the prevalence stayed constant. The Prevent macro-simulation model was used.
Over the period 2016-2045, 205,000 cancer cases out of the 2.1 million expected for the 13 cancer sites (9.5%) that have been studied, could be avoided in the Nordic countries by totally eliminating overweight and obesity in the target population. The largest proportional impact was found for oesophageal adenocarcinoma (24%), and the highest absolute impact was observed for colon (44638) and postmenopausal breast cancer (41135).
Decreased prevalence of overweight and obesity would reduce the cancer burden in the Nordic countries. The results from this study form an important step to increase awareness and priorities in cancer control by controlling overweight and obesity in the population.
几种癌症与超重和肥胖存在因果关系,而超重和肥胖在北欧国家呈上升趋势。本研究的目的是量化北欧国家与超重和肥胖相关的癌症负担比例,并估计癌症预防的潜力。
在超重和肥胖的不同流行率情景下,对未来30年(即2016 - 2045年)北欧国家13个癌症部位的癌症病例数进行估计,并与流行率保持不变时预计的癌症病例数进行比较。使用了Prevent宏观模拟模型。
在2016 - 2045年期间,如果完全消除目标人群中的超重和肥胖,在北欧国家,所研究的13个癌症部位预计的210万例癌症病例中,有20.5万例(9.5%)可以避免。食管腺癌的比例影响最大(24%),结肠癌(44638例)和绝经后乳腺癌(41135例)的绝对影响最高。
超重和肥胖流行率的降低将减轻北欧国家的癌症负担。本研究结果是通过控制人群中的超重和肥胖来提高癌症控制意识和优先级的重要一步。